TRPM Family Channels in Cancer

Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca(2+) and Mg(2+), with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers...

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Detalles Bibliográficos
Autores principales: Hantute-Ghesquier, Aline, Haustrate, Aurélien, Prevarskaya, Natalia, Lehen’kyi, V’yacheslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027338/
https://www.ncbi.nlm.nih.gov/pubmed/29875336
http://dx.doi.org/10.3390/ph11020058
Descripción
Sumario:Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca(2+) and Mg(2+), with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers such as prostate cancer for mostly TRPM8 and TRPM2, breast cancer for mostly TRPM2 and TRPM7, and pancreatic cancer for TRPM2/7/8 channels. The role of TRPM5 channels has been shown in lung cancer, TRPM1 in melanoma, and TRPM4 channel in prostate cancer as well. Thus, the TRPM family of channels may represent an appealing target for the anticancer therapy.

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