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Location, Location, Location: Signals in Muscle Specification
Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific time and space. Although the anatomical structure of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027348/ https://www.ncbi.nlm.nih.gov/pubmed/29783715 http://dx.doi.org/10.3390/jdb6020011 |
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author | Chang, Chih-Ning Kioussi, Chrissa |
author_facet | Chang, Chih-Ning Kioussi, Chrissa |
author_sort | Chang, Chih-Ning |
collection | PubMed |
description | Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific time and space. Although the anatomical structure of skeletal muscles is similar, their functions and locations are specialized. This is the result of specific signaling as the embryo grows and cells migrate to form different structures and organs. As cells progress to their next state, they suppress current sequence specific transcription factors (SSTF) and construct new networks to establish new myogenic features. In this review, we provide an overview of signaling pathways and gene regulatory networks during formation of the craniofacial, cardiac, vascular, trunk, and limb skeletal muscles. |
format | Online Article Text |
id | pubmed-6027348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60273482018-07-13 Location, Location, Location: Signals in Muscle Specification Chang, Chih-Ning Kioussi, Chrissa J Dev Biol Review Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific time and space. Although the anatomical structure of skeletal muscles is similar, their functions and locations are specialized. This is the result of specific signaling as the embryo grows and cells migrate to form different structures and organs. As cells progress to their next state, they suppress current sequence specific transcription factors (SSTF) and construct new networks to establish new myogenic features. In this review, we provide an overview of signaling pathways and gene regulatory networks during formation of the craniofacial, cardiac, vascular, trunk, and limb skeletal muscles. MDPI 2018-05-18 /pmc/articles/PMC6027348/ /pubmed/29783715 http://dx.doi.org/10.3390/jdb6020011 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chang, Chih-Ning Kioussi, Chrissa Location, Location, Location: Signals in Muscle Specification |
title | Location, Location, Location: Signals in Muscle Specification |
title_full | Location, Location, Location: Signals in Muscle Specification |
title_fullStr | Location, Location, Location: Signals in Muscle Specification |
title_full_unstemmed | Location, Location, Location: Signals in Muscle Specification |
title_short | Location, Location, Location: Signals in Muscle Specification |
title_sort | location, location, location: signals in muscle specification |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027348/ https://www.ncbi.nlm.nih.gov/pubmed/29783715 http://dx.doi.org/10.3390/jdb6020011 |
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