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Location, Location, Location: Signals in Muscle Specification

Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific time and space. Although the anatomical structure of...

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Detalles Bibliográficos
Autores principales: Chang, Chih-Ning, Kioussi, Chrissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027348/
https://www.ncbi.nlm.nih.gov/pubmed/29783715
http://dx.doi.org/10.3390/jdb6020011
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author Chang, Chih-Ning
Kioussi, Chrissa
author_facet Chang, Chih-Ning
Kioussi, Chrissa
author_sort Chang, Chih-Ning
collection PubMed
description Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific time and space. Although the anatomical structure of skeletal muscles is similar, their functions and locations are specialized. This is the result of specific signaling as the embryo grows and cells migrate to form different structures and organs. As cells progress to their next state, they suppress current sequence specific transcription factors (SSTF) and construct new networks to establish new myogenic features. In this review, we provide an overview of signaling pathways and gene regulatory networks during formation of the craniofacial, cardiac, vascular, trunk, and limb skeletal muscles.
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spelling pubmed-60273482018-07-13 Location, Location, Location: Signals in Muscle Specification Chang, Chih-Ning Kioussi, Chrissa J Dev Biol Review Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific time and space. Although the anatomical structure of skeletal muscles is similar, their functions and locations are specialized. This is the result of specific signaling as the embryo grows and cells migrate to form different structures and organs. As cells progress to their next state, they suppress current sequence specific transcription factors (SSTF) and construct new networks to establish new myogenic features. In this review, we provide an overview of signaling pathways and gene regulatory networks during formation of the craniofacial, cardiac, vascular, trunk, and limb skeletal muscles. MDPI 2018-05-18 /pmc/articles/PMC6027348/ /pubmed/29783715 http://dx.doi.org/10.3390/jdb6020011 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chang, Chih-Ning
Kioussi, Chrissa
Location, Location, Location: Signals in Muscle Specification
title Location, Location, Location: Signals in Muscle Specification
title_full Location, Location, Location: Signals in Muscle Specification
title_fullStr Location, Location, Location: Signals in Muscle Specification
title_full_unstemmed Location, Location, Location: Signals in Muscle Specification
title_short Location, Location, Location: Signals in Muscle Specification
title_sort location, location, location: signals in muscle specification
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027348/
https://www.ncbi.nlm.nih.gov/pubmed/29783715
http://dx.doi.org/10.3390/jdb6020011
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