Cargando…

A Miniaturized Extruder to Prototype Amorphous Solid Dispersions: Selection of Plasticizers for Hot Melt Extrusion

Hot-melt extrusion is an option to fabricate amorphous solid dispersions and to enhance oral bioavailability of poorly soluble compounds. The selection of suitable polymer carriers and processing aids determines the dissolution, homogeneity and stability performance of this solid dosage form. A mini...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lauer, Matthias E., Maurer, Reto, De Paepe, Anne T., Stillhart, Cordula, Jacob, Laurence, James, Rajesh, Kojima, Yuki, Rietmann, Rene, Kissling, Tom, van den Ende, Joost A., Schwarz, Sabine, Grassmann, Olaf, Page, Susanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027370/ https://www.ncbi.nlm.nih.gov/pubmed/29783755 http://dx.doi.org/10.3390/pharmaceutics10020058

Ejemplares similares

Formulation and Evaluation of Fenbendazole Extended-Release Extrudes Processed by Hot-Melt Extrusion
por: Bezerra, Gilberto S. N., et al.
Publicado: (2022)

Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan
por: Giri, Bhupendra Raj, et al.
Publicado: (2021)

The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing Rivaroxaban in Combination with Polymers
por: Lee, Jong-Hwa, et al.
Publicado: (2021)

Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of Polymers
por: Kramarczyk, Daniel, et al.
Publicado: (2023)

Dissolution-permeation of hot-melt extruded amorphous solid dispersion comprising an experimental grade of HPMCAS
por: Tanaka, Hironori, et al.
Publicado: (2023)

Influence of Carbamazepine Dihydrate on the Preparation of Amorphous Solid Dispersions by Hot Melt Extrusion
por: Ma, Xiangyu, et al.
Publicado: (2020)

Processing of Polyvinyl Acetate Phthalate in Hot-Melt Extrusion—Preparation of Amorphous Solid Dispersions
por: Monschke, Marius, et al.
Publicado: (2020)

Physicochemical and Biochemical Evaluation of Amorphous Solid Dispersion of Naringenin Prepared Using Hot-Melt Extrusion
por: Ishimoto, Kenji, et al.
Publicado: (2022)

Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation
por: Fule, Ritesh, et al.
Publicado: (2014)

Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics
por: Fule, Ritesh A., et al.
Publicado: (2013)

Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying
por: Schönfeld, Barbara V., et al.
Publicado: (2021)

A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development
por: Kyeremateng, Samuel O., et al.
Publicado: (2022)

Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement
por: Ponnammal, Poovizhi, et al.
Publicado: (2018)

Preparation of Azithromycin Amorphous Solid Dispersion by Hot-Melt Extrusion: An Advantageous Technology with Taste Masking and Solubilization Effects
por: Li, Jiale, et al.
Publicado: (2022)

The applications of machine learning to predict the forming of chemically stable amorphous solid dispersions prepared by hot-melt extrusion
por: Jiang, Junhuang, et al.
Publicado: (2023)

Predicting Throughput and Melt Temperature in Pharmaceutical Hot Melt Extrusion
por: Gottschalk, Tobias, et al.
Publicado: (2022)

Hot Melt Coating of Amorphous Carvedilol
por: Bannow, Jacob, et al.
Publicado: (2020)

Factors That Influence Sustained Release from Hot-Melt Extrudates
por: Mansuroglu, Yaser, et al.
Publicado: (2023)

Hot Melt Extrusion: Highlighting Physicochemical Factors to Be Investigated While Designing and Optimizing a Hot Melt Extrusion Process
por: Censi, Roberta, et al.
Publicado: (2018)

Downstream Processing of Itraconazole:HPMCAS Amorphous Solid Dispersion: From Hot-Melt Extrudate to Tablet Using a Quality by Design Approach
por: Mishra, Saurabh M, et al.
Publicado: (2022)

Application of the combination of ball-milling and hot-melt extrusion in the development of an amorphous solid dispersion of a poorly water-soluble drug with high melting point
por: Fan, Wenling, et al.
Publicado: (2019)

Predicting Residence Time and Melt Temperature in Pharmaceutical Hot Melt Extrusion
por: Winck, Judith, et al.
Publicado: (2023)

A Rational Design of a Biphasic Dissolution Setup—Modelling of Biorelevant Kinetics for a Ritonavir Hot-Melt Extruded Amorphous Solid Dispersion
por: Denninger, Alexander, et al.
Publicado: (2020)

Towards predicting the product quality in hot-melt extrusion: Small scale extrusion
por: Matić, Josip, et al.
Publicado: (2020)

Hot-Melt Extrusion as an Effective Technique for Obtaining an Amorphous System of Curcumin and Piperine with Improved Properties Essential for Their Better Biological Activities
por: Wdowiak, Kamil, et al.
Publicado: (2023)

Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation
por: Bochmann, Esther S., et al.
Publicado: (2018)

Towards predicting the product quality in hot-melt extrusion: Pilot plant scale extrusion
por: Matić, Josip, et al.
Publicado: (2021)

Bioanalytical Workflow for Qualitative and Quantitative Assessment of Hot-Melt Extruded Lysozyme Formulations
por: Elsayed, Yomnah Y., et al.
Publicado: (2022)

Highly protein-loaded melt extrudates produced by small-scale ram and twin-screw extrusion - evaluation of extrusion process design on protein stability by experimental and numerical approaches
por: Dauer, Katharina, et al.
Publicado: (2023)

Inline Determination of Residence Time Distribution in Hot-Melt-Extrusion
por: Wesholowski, Jens, et al.
Publicado: (2018)

Novel Cleaning-in-Place Strategies for Pharmaceutical Hot Melt Extrusion
por: Spoerk, Martin, et al.
Publicado: (2020)

Hot Melt Extrusion-Triggered Amorphization as a Continuous Process for Inducing Extended Supersaturable Drug Immediate-Release from saSMSDs Systems
por: Yu, Huan, et al.
Publicado: (2022)

HPMCAS-Based Amorphous Solid Dispersions in Clinic: A Review on Manufacturing Techniques (Hot Melt Extrusion and Spray Drying), Marketed Products and Patents
por: Corrie, Leander, et al.
Publicado: (2023)

Effects of hot-melt extruded nano-copper on the Cu bioavailability and growth of broiler chickens
por: Lee, JunHyung, et al.
Publicado: (2021)

Effects of Extrusion Conditions on the Physicochemical Properties of Extruded Red Ginseng
por: Gui, Ying, et al.
Publicado: (2012)

Material-Preserving Extrusion of Polyamide on a Twin-Screw Extruder
por: Schall, Christoph, et al.
Publicado: (2023)

Development and Evaluation of Amorphous Oral Thin Films Using Solvent-Free Processes: Comparison between 3D Printing and Hot-Melt Extrusion Technologies
por: Zhang, Jiaxiang, et al.
Publicado: (2021)

Melt Conveying in Single-Screw Extruders: Modeling and Simulation
por: Marschik, Christian, et al.
Publicado: (2022)

A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products
por: Maniruzzaman, Mohammed, et al.
Publicado: (2012)

Innovations in Thermal Processing: Hot-Melt Extrusion and KinetiSol® Dispersing
por: Tan, Deck Khong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kr7r3djaa73au0e4s99fo0ghnd