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Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency

The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. In a 46, XY patient with female external genitalia, together with a loss of function mutation S441P, we identified a novel missense m...

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Detalles Bibliográficos
Autores principales:	Fernández-Cancio, Mónica, Camats, Núria, Flück, Christa E., Zalewski, Adam, Dick, Bernhard, Frey, Brigitte M., Monné, Raquel, Torán, Núria, Audí, Laura, Pandey, Amit V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027421/ https://www.ncbi.nlm.nih.gov/pubmed/29710837 http://dx.doi.org/10.3390/ph11020037

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