A Repurposed Drug for Brain Cancer: Enhanced Atovaquone Amorphous Solid Dispersion by Combining a Spontaneously Emulsifying Component with a Polymer Carrier

Glioblastoma multiforme (GBM) is the most common and lethal central nervous system tumor. Recently, atovaquone has shown inhibition of signal transducer and activator transcription 3, a promising target for GBM therapy. However, it is currently unable to achieve therapeutic drug concentrations in th...

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Detalles Bibliográficos
Autores principales: Takabe, Hiroyuki, Warnken, Zachary N., Zhang, Yajie, Davis, Daniel A., Smyth, Hugh D. C., Kuhn, John G., Weitman, Steve, Williams III, Robert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027483/
https://www.ncbi.nlm.nih.gov/pubmed/29783757
http://dx.doi.org/10.3390/pharmaceutics10020060

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