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The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cyc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027508/ https://www.ncbi.nlm.nih.gov/pubmed/29614775 http://dx.doi.org/10.3390/pathogens7020036 |
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author | Marchese, Letícia Nascimento, Janaina de Freitas Damasceno, Flávia Silva Bringaud, Frédéric Michels, Paul A. M. Silber, Ariel Mariano |
author_facet | Marchese, Letícia Nascimento, Janaina de Freitas Damasceno, Flávia Silva Bringaud, Frédéric Michels, Paul A. M. Silber, Ariel Mariano |
author_sort | Marchese, Letícia |
collection | PubMed |
description | Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts. |
format | Online Article Text |
id | pubmed-6027508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60275082018-07-13 The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids Marchese, Letícia Nascimento, Janaina de Freitas Damasceno, Flávia Silva Bringaud, Frédéric Michels, Paul A. M. Silber, Ariel Mariano Pathogens Review Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts. MDPI 2018-04-01 /pmc/articles/PMC6027508/ /pubmed/29614775 http://dx.doi.org/10.3390/pathogens7020036 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marchese, Letícia Nascimento, Janaina de Freitas Damasceno, Flávia Silva Bringaud, Frédéric Michels, Paul A. M. Silber, Ariel Mariano The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids |
title | The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids |
title_full | The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids |
title_fullStr | The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids |
title_full_unstemmed | The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids |
title_short | The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids |
title_sort | uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027508/ https://www.ncbi.nlm.nih.gov/pubmed/29614775 http://dx.doi.org/10.3390/pathogens7020036 |
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