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The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids

Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cyc...

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Autores principales: Marchese, Letícia, Nascimento, Janaina de Freitas, Damasceno, Flávia Silva, Bringaud, Frédéric, Michels, Paul A. M., Silber, Ariel Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027508/
https://www.ncbi.nlm.nih.gov/pubmed/29614775
http://dx.doi.org/10.3390/pathogens7020036
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author Marchese, Letícia
Nascimento, Janaina de Freitas
Damasceno, Flávia Silva
Bringaud, Frédéric
Michels, Paul A. M.
Silber, Ariel Mariano
author_facet Marchese, Letícia
Nascimento, Janaina de Freitas
Damasceno, Flávia Silva
Bringaud, Frédéric
Michels, Paul A. M.
Silber, Ariel Mariano
author_sort Marchese, Letícia
collection PubMed
description Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.
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spelling pubmed-60275082018-07-13 The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids Marchese, Letícia Nascimento, Janaina de Freitas Damasceno, Flávia Silva Bringaud, Frédéric Michels, Paul A. M. Silber, Ariel Mariano Pathogens Review Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts. MDPI 2018-04-01 /pmc/articles/PMC6027508/ /pubmed/29614775 http://dx.doi.org/10.3390/pathogens7020036 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marchese, Letícia
Nascimento, Janaina de Freitas
Damasceno, Flávia Silva
Bringaud, Frédéric
Michels, Paul A. M.
Silber, Ariel Mariano
The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_full The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_fullStr The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_full_unstemmed The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_short The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids
title_sort uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027508/
https://www.ncbi.nlm.nih.gov/pubmed/29614775
http://dx.doi.org/10.3390/pathogens7020036
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