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Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect

Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug...

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Detalles Bibliográficos
Autores principales: Sharma, Divakar, Bisht, Deepa, Khan, Asad U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027512/
https://www.ncbi.nlm.nih.gov/pubmed/29843395
http://dx.doi.org/10.3390/proteomes6020026
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author Sharma, Divakar
Bisht, Deepa
Khan, Asad U.
author_facet Sharma, Divakar
Bisht, Deepa
Khan, Asad U.
author_sort Sharma, Divakar
collection PubMed
description Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug resistance but some resistance mechanisms are still unknown. Recently approved line probe assay (LPA) diagnostics for detecting the resistance to first and second line drugs are unable to diagnose the drug resistance in M. tuberculosis isolates which do not have the mutations in particular genes responsible for resistance. Proteomics and bioinformatic tools emerged as direct approaches for identification and characterization of novel proteins which are directly and indirectly involved in drug resistance that could be used as potential targets in future. In future, these novel targets might reveal new mechanism of resistance and can be used in diagnostics or as drug targets.
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spelling pubmed-60275122018-07-13 Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect Sharma, Divakar Bisht, Deepa Khan, Asad U. Proteomes Review Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug resistance but some resistance mechanisms are still unknown. Recently approved line probe assay (LPA) diagnostics for detecting the resistance to first and second line drugs are unable to diagnose the drug resistance in M. tuberculosis isolates which do not have the mutations in particular genes responsible for resistance. Proteomics and bioinformatic tools emerged as direct approaches for identification and characterization of novel proteins which are directly and indirectly involved in drug resistance that could be used as potential targets in future. In future, these novel targets might reveal new mechanism of resistance and can be used in diagnostics or as drug targets. MDPI 2018-05-28 /pmc/articles/PMC6027512/ /pubmed/29843395 http://dx.doi.org/10.3390/proteomes6020026 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sharma, Divakar
Bisht, Deepa
Khan, Asad U.
Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect
title Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect
title_full Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect
title_fullStr Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect
title_full_unstemmed Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect
title_short Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect
title_sort potential alternative strategy against drug resistant tuberculosis: a proteomics prospect
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027512/
https://www.ncbi.nlm.nih.gov/pubmed/29843395
http://dx.doi.org/10.3390/proteomes6020026
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