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Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect
Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027512/ https://www.ncbi.nlm.nih.gov/pubmed/29843395 http://dx.doi.org/10.3390/proteomes6020026 |
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author | Sharma, Divakar Bisht, Deepa Khan, Asad U. |
author_facet | Sharma, Divakar Bisht, Deepa Khan, Asad U. |
author_sort | Sharma, Divakar |
collection | PubMed |
description | Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug resistance but some resistance mechanisms are still unknown. Recently approved line probe assay (LPA) diagnostics for detecting the resistance to first and second line drugs are unable to diagnose the drug resistance in M. tuberculosis isolates which do not have the mutations in particular genes responsible for resistance. Proteomics and bioinformatic tools emerged as direct approaches for identification and characterization of novel proteins which are directly and indirectly involved in drug resistance that could be used as potential targets in future. In future, these novel targets might reveal new mechanism of resistance and can be used in diagnostics or as drug targets. |
format | Online Article Text |
id | pubmed-6027512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60275122018-07-13 Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect Sharma, Divakar Bisht, Deepa Khan, Asad U. Proteomes Review Mycobacterium tuberculosis is one of the deadliest human pathogen of the tuberculosis diseases. Drug resistance leads to emergence of multidrug-resistant and extremely drug resistant strains of M. tuberculosis. Apart from principal targets of resistance, many explanations have been proposed for drug resistance but some resistance mechanisms are still unknown. Recently approved line probe assay (LPA) diagnostics for detecting the resistance to first and second line drugs are unable to diagnose the drug resistance in M. tuberculosis isolates which do not have the mutations in particular genes responsible for resistance. Proteomics and bioinformatic tools emerged as direct approaches for identification and characterization of novel proteins which are directly and indirectly involved in drug resistance that could be used as potential targets in future. In future, these novel targets might reveal new mechanism of resistance and can be used in diagnostics or as drug targets. MDPI 2018-05-28 /pmc/articles/PMC6027512/ /pubmed/29843395 http://dx.doi.org/10.3390/proteomes6020026 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sharma, Divakar Bisht, Deepa Khan, Asad U. Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
title | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
title_full | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
title_fullStr | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
title_full_unstemmed | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
title_short | Potential Alternative Strategy against Drug Resistant Tuberculosis: A Proteomics Prospect |
title_sort | potential alternative strategy against drug resistant tuberculosis: a proteomics prospect |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027512/ https://www.ncbi.nlm.nih.gov/pubmed/29843395 http://dx.doi.org/10.3390/proteomes6020026 |
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