Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

Parkinson disease (PD) is the second most common neurodegenerative disorder and the leading neurodegenerative cause of motor disability. Pathologic accumulation of aggregated alpha synuclein (AS) protein in brain, and imbalance in the nigrostriatal system due to the loss of dopaminergic neurons in t...

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Detalles Bibliográficos
Autores principales: Jan, Asad, Jansonius, Brandon, Delaidelli, Alberto, Bhanshali, Forum, An, Yi Andy, Ferreira, Nelson, Smits, Lisa M., Negri, Gian Luca, Schwamborn, Jens C., Jensen, Poul H., Mackenzie, Ian R., Taubert, Stefan, Sorensen, Poul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027557/
https://www.ncbi.nlm.nih.gov/pubmed/29961428
http://dx.doi.org/10.1186/s40478-018-0554-9

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