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Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry
This review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027677/ https://www.ncbi.nlm.nih.gov/pubmed/29903979 http://dx.doi.org/10.3390/scipharm86020026 |
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author | Kryshchyshyn, Anna Roman, Olexandra Lozynskyi, Andrii Lesyk, Roman |
author_facet | Kryshchyshyn, Anna Roman, Olexandra Lozynskyi, Andrii Lesyk, Roman |
author_sort | Kryshchyshyn, Anna |
collection | PubMed |
description | This review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view, they are perfect heterodienes to undergo hetero-Diels–Alder reaction with a variety of dienophiles, yielding regio- and diastereoselectively thiopyranothiazole scaffolds. The annealing of thiazole and thiopyran cycles in condensed heterosystem is a precondition for the “centers conservative” creation of the ligand-target binding complex and can promote a potential selectivity to biotargets. The review covers possible therapeutic applications of thiopyrano[2,3-d]thiazoles, such as anti-inflammatory, antibacterial, anticancer as well as aniparasitic activities. Thus, thiopyrano[2,3-d]thiazoles may be used as powerful tools in the development of biologically active agents and drug-like molecules. |
format | Online Article Text |
id | pubmed-6027677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60276772018-07-02 Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry Kryshchyshyn, Anna Roman, Olexandra Lozynskyi, Andrii Lesyk, Roman Sci Pharm Review This review presents the up to date development of fused thiopyranothiazoles that comprise one of the thiazolidine derivatives classes. Thiazolidine and thiazolidinone-related compounds belong to the widely studied heterocycles from a medicinal chemistry perspective. From the chemical point of view, they are perfect heterodienes to undergo hetero-Diels–Alder reaction with a variety of dienophiles, yielding regio- and diastereoselectively thiopyranothiazole scaffolds. The annealing of thiazole and thiopyran cycles in condensed heterosystem is a precondition for the “centers conservative” creation of the ligand-target binding complex and can promote a potential selectivity to biotargets. The review covers possible therapeutic applications of thiopyrano[2,3-d]thiazoles, such as anti-inflammatory, antibacterial, anticancer as well as aniparasitic activities. Thus, thiopyrano[2,3-d]thiazoles may be used as powerful tools in the development of biologically active agents and drug-like molecules. MDPI 2018-06-14 2018 /pmc/articles/PMC6027677/ /pubmed/29903979 http://dx.doi.org/10.3390/scipharm86020026 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kryshchyshyn, Anna Roman, Olexandra Lozynskyi, Andrii Lesyk, Roman Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
title | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
title_full | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
title_fullStr | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
title_full_unstemmed | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
title_short | Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry |
title_sort | thiopyrano[2,3-d]thiazoles as new efficient scaffolds in medicinal chemistry |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027677/ https://www.ncbi.nlm.nih.gov/pubmed/29903979 http://dx.doi.org/10.3390/scipharm86020026 |
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