Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling

The study by Mason et al. in this issue used mechanistic modeling and simulation to address how both the dose of acetaminophen consumed and the time since ingestion can be estimated from biomarkers measured in a single serum sample in mice. Translation into the clinic would potentially be an advance...

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Detalles Bibliográficos
Autor principal: Watkins, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027730/
https://www.ncbi.nlm.nih.gov/pubmed/29700994
http://dx.doi.org/10.1002/psp4.12303
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author Watkins, Paul B.
author_facet Watkins, Paul B.
author_sort Watkins, Paul B.
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description The study by Mason et al. in this issue used mechanistic modeling and simulation to address how both the dose of acetaminophen consumed and the time since ingestion can be estimated from biomarkers measured in a single serum sample in mice. Translation into the clinic would potentially be an advance in the treatment of acetaminophen poisoning. Importantly, this approach could transform the evaluation of liver safety in clinical trials of new drug candidates.
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spelling pubmed-60277302018-07-06 Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling Watkins, Paul B. CPT Pharmacometrics Syst Pharmacol Perspectives The study by Mason et al. in this issue used mechanistic modeling and simulation to address how both the dose of acetaminophen consumed and the time since ingestion can be estimated from biomarkers measured in a single serum sample in mice. Translation into the clinic would potentially be an advance in the treatment of acetaminophen poisoning. Importantly, this approach could transform the evaluation of liver safety in clinical trials of new drug candidates. John Wiley and Sons Inc. 2018-04-26 2018-06 /pmc/articles/PMC6027730/ /pubmed/29700994 http://dx.doi.org/10.1002/psp4.12303 Text en © 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspectives
Watkins, Paul B.
Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling
title Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling
title_full Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling
title_fullStr Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling
title_full_unstemmed Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling
title_short Improving Interpretation of New and Old Serum Biomarkers of Drug‐Induced Liver Injury Through Mechanistic Modeling
title_sort improving interpretation of new and old serum biomarkers of drug‐induced liver injury through mechanistic modeling
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027730/
https://www.ncbi.nlm.nih.gov/pubmed/29700994
http://dx.doi.org/10.1002/psp4.12303
work_keys_str_mv AT watkinspaulb improvinginterpretationofnewandoldserumbiomarkersofdruginducedliverinjurythroughmechanisticmodeling

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