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First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

To predict first‐pass and systemic cytochrome P450 (CYP) 3A‐mediated metabolism of midazolam in preterm neonates, a physiological population pharmacokinetic model was developed describing intestinal and hepatic midazolam clearance in preterm infants. On the basis of midazolam and 1‐OH‐midazolam conc...

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Detalles Bibliográficos
Autores principales:	Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., de Roos, Berend, Brill, Margreke J. E., van den Anker, Johannes N., Rostami‐Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027733/ https://www.ncbi.nlm.nih.gov/pubmed/29745466 http://dx.doi.org/10.1002/psp4.12295

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