Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice

BACKGROUND: Genomic imprinting is governed by allele-specific DNA methylation at imprinting control regions (ICRs), and the mechanism controlling its differential methylation establishment during gametogenesis has been a subject of intensive research interest. However, recent studies have reported t...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsuzaki, Hitomi, Okamura, Eiichi, Kuramochi, Daichi, Ushiki, Aki, Hirakawa, Katsuhiko, Fukamizu, Akiyoshi, Tanimoto, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027785/
https://www.ncbi.nlm.nih.gov/pubmed/29958543
http://dx.doi.org/10.1186/s13072-018-0207-z

Ejemplares similares

Ejemplares similares