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Uremic pruritus and associated factors in hemodialysis patients: A multi-center study

BACKGROUND: Uremic pruritus is a common and disturbing problem in hemodialysis patients. Although its pathogenesis is not completely understood, it is thought to be multifactorial. The aim of this study was to identify risk factors of uremic pruritus in hemodialysis patients. METHODS: A total of 249...

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Autores principales: Ozen, Nurten, Cinar, Fatma Ilknur, Askin, Dilek, Mut, Dilek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Nephrology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027816/
https://www.ncbi.nlm.nih.gov/pubmed/29971209
http://dx.doi.org/10.23876/j.krcp.2018.37.2.138
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author Ozen, Nurten
Cinar, Fatma Ilknur
Askin, Dilek
Mut, Dilek
author_facet Ozen, Nurten
Cinar, Fatma Ilknur
Askin, Dilek
Mut, Dilek
author_sort Ozen, Nurten
collection PubMed
description BACKGROUND: Uremic pruritus is a common and disturbing problem in hemodialysis patients. Although its pathogenesis is not completely understood, it is thought to be multifactorial. The aim of this study was to identify risk factors of uremic pruritus in hemodialysis patients. METHODS: A total of 249 patients from four dialysis centers were included in this study. Data were collected using a questionnaire, the visual analogue scale, and the Hospital Anxiety and Depression Scale. We investigated whether socio-demographic and biochemical parameters were correlated to uremic pruritus. RESULTS: Pruritus was present in 53.4% of the hemodialysis patients. The mean visual analogue scale severity was 6.47 ± 1.56. Patients with white blood cell (WBC) counts > 6.7 × 10(3)/μL had 1.73 times (95% confidence interval [CI], 1.360–2.888; P = 0.036) more pruritus than did those with WBC counts < 6.7 × 10(3)/μL. Patients with dry skin were 0.2 times (95% CI, 0.070–0.182; P = 0.028) more likely to suffer from very severe pruritus than were those with normal skin. CONCLUSION: Uremic pruritus remains a serious problem in dialysis patients. The WBC level and presence of dry skin are thought to be among its causes. Therefore, data regarding the possible risk factors of uremic pruritus must be followed closely in patients at risk.
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spelling pubmed-60278162018-07-03 Uremic pruritus and associated factors in hemodialysis patients: A multi-center study Ozen, Nurten Cinar, Fatma Ilknur Askin, Dilek Mut, Dilek Kidney Res Clin Pract Original Article BACKGROUND: Uremic pruritus is a common and disturbing problem in hemodialysis patients. Although its pathogenesis is not completely understood, it is thought to be multifactorial. The aim of this study was to identify risk factors of uremic pruritus in hemodialysis patients. METHODS: A total of 249 patients from four dialysis centers were included in this study. Data were collected using a questionnaire, the visual analogue scale, and the Hospital Anxiety and Depression Scale. We investigated whether socio-demographic and biochemical parameters were correlated to uremic pruritus. RESULTS: Pruritus was present in 53.4% of the hemodialysis patients. The mean visual analogue scale severity was 6.47 ± 1.56. Patients with white blood cell (WBC) counts > 6.7 × 10(3)/μL had 1.73 times (95% confidence interval [CI], 1.360–2.888; P = 0.036) more pruritus than did those with WBC counts < 6.7 × 10(3)/μL. Patients with dry skin were 0.2 times (95% CI, 0.070–0.182; P = 0.028) more likely to suffer from very severe pruritus than were those with normal skin. CONCLUSION: Uremic pruritus remains a serious problem in dialysis patients. The WBC level and presence of dry skin are thought to be among its causes. Therefore, data regarding the possible risk factors of uremic pruritus must be followed closely in patients at risk. Korean Society of Nephrology 2018-06 2018-06-30 /pmc/articles/PMC6027816/ /pubmed/29971209 http://dx.doi.org/10.23876/j.krcp.2018.37.2.138 Text en Copyright © 2018 by The Korean Society of Nephrology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ozen, Nurten
Cinar, Fatma Ilknur
Askin, Dilek
Mut, Dilek
Uremic pruritus and associated factors in hemodialysis patients: A multi-center study
title Uremic pruritus and associated factors in hemodialysis patients: A multi-center study
title_full Uremic pruritus and associated factors in hemodialysis patients: A multi-center study
title_fullStr Uremic pruritus and associated factors in hemodialysis patients: A multi-center study
title_full_unstemmed Uremic pruritus and associated factors in hemodialysis patients: A multi-center study
title_short Uremic pruritus and associated factors in hemodialysis patients: A multi-center study
title_sort uremic pruritus and associated factors in hemodialysis patients: a multi-center study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027816/
https://www.ncbi.nlm.nih.gov/pubmed/29971209
http://dx.doi.org/10.23876/j.krcp.2018.37.2.138
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