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Direct modulation of myelin-autoreactive CD4(+) and CD8(+) T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules

PURPOSE: Numerous nanomaterials have been reported in the treatment of multiple sclerosis or experimental autoimmune encephalomyelitis (EAE). But most of these nanoscale therapeutics deliver myelin antigens together with toxins or cytokines and underlay the cellular uptake and induction of tolerogen...

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Detalles Bibliográficos
Autores principales:	Pei, Weiya, Wan, Xin, Shahzad, Khawar Ali, Zhang, Lei, Song, Shilong, Jin, Xiaoxiao, Wang, Limin, Zhao, Chen, Shen, Chuanlai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027825/ https://www.ncbi.nlm.nih.gov/pubmed/29983566 http://dx.doi.org/10.2147/IJN.S164500

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