Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)

Lysosomal phospholipase A2 (LPLA(2)) is characterized by broad substrate recognition, peak activity at acidic pH, and the transacylation of lipophilic alcohols, especially N-acetyl-sphingosine. Prior structural analysis of LPLA(2) revealed the presence of an atypical acidic residue, Asp13, in the ot...

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Detalles Bibliográficos
Autores principales: Hinkovska-Galcheva, Vania, Kelly, Robert, Manthei, Kelly A., Bouley, Renee, Yuan, Wenmin, Schwendeman, Anna, Tesmer, John J. G., Shayman, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027918/
https://www.ncbi.nlm.nih.gov/pubmed/29724779
http://dx.doi.org/10.1194/jlr.M084012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027918/
https://www.ncbi.nlm.nih.gov/pubmed/29724779
http://dx.doi.org/10.1194/jlr.M084012

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