Cargando…

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A(2)

Lysosomal phospholipase A2 (LPLA(2)) is characterized by broad substrate recognition, peak activity at acidic pH, and the transacylation of lipophilic alcohols, especially N-acetyl-sphingosine. Prior structural analysis of LPLA(2) revealed the presence of an atypical acidic residue, Asp13, in the ot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hinkovska-Galcheva, Vania, Kelly, Robert, Manthei, Kelly A., Bouley, Renee, Yuan, Wenmin, Schwendeman, Anna, Tesmer, John J. G., Shayman, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027918/ https://www.ncbi.nlm.nih.gov/pubmed/29724779 http://dx.doi.org/10.1194/jlr.M084012

Ejemplares similares

Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase
por: Glukhova, Alisa, et al.
Publicado: (2015)

Inhibition of lysosomal phospholipase A2 predicts drug-induced phospholipidosis
por: Hinkovska-Galcheva, Vania, et al.
Publicado: (2021)

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
por: Manthei, Kelly A, et al.
Publicado: (2018)

Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles
por: Manthei, Kelly A., et al.
Publicado: (2020)

The position of lysosomes within the cell determines their luminal pH
por: Johnson, Danielle E., et al.
Publicado: (2016)

Acyl Chain Specificity of Marine Streptomyces klenkii PhosPholipase D and Its Application in Enzymatic Preparation of Phosphatidylserine
por: Hu, Rongkang, et al.
Publicado: (2021)

Intracellular Phospholipase A(1) and Acyltransferase, Which Are Involved in Caenorhabditis elegans Stem Cell Divisions, Determine the sn-1 Fatty Acyl Chain of Phosphatidylinositol
por: Imae, Rieko, et al.
Publicado: (2010)

A model of lysosomal pH regulation
por: Ishida, Yoichi, et al.
Publicado: (2013)

The Effects of pH and Excipients on Exenatide Stability in Solution
por: Benet, Alexander, et al.
Publicado: (2021)

Acyl Chains of Phospholipase D Transphosphatidylation Products in Arabidopsis Cells: A Study Using Multiple Reaction Monitoring Mass Spectrometry
por: Rainteau, Dominique, et al.
Publicado: (2012)

Glutamine Produces Ammonium to Tune Lysosomal pH and Regulate Lysosomal Function
por: Xiong, Jian, et al.
Publicado: (2022)

Lysine fatty acylation promotes lysosomal targeting of TNF-α
por: Jiang, Hong, et al.
Publicado: (2016)

Characterization of N-Acyl Phosphatidylethanolamine-Specific Phospholipase-D Isoforms in the Nematode Caenorhabditis elegans
por: Harrison, Neale, et al.
Publicado: (2014)

Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking
por: Schmieder, Stefanie S., et al.
Publicado: (2022)

Cannabidiol's Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D
por: Leishman, Emma, et al.
Publicado: (2018)

Structure of human saposin A at lysosomal pH
por: Hill, Chris H., et al.
Publicado: (2015)

Capsaicin-sensitive primary sensory neurons in the mouse express N-Acyl phosphatidylethanolamine phospholipase D
por: Nagy, B., et al.
Publicado: (2009)

Lipid Acyl Chain Remodeling in Yeast
por: Renne, Mike F., et al.
Publicado: (2016)

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
por: Garrity, Abigail G, et al.
Publicado: (2016)

Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH
por: Chin, Marcus Y., et al.
Publicado: (2021)

Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content
por: Mundy, Dorothy I., et al.
Publicado: (2012)

An Autoinhibitory Helix in the C-Terminal Region of Phospholipase C-β Mediates Gα(q) Activation
por: Lyon, Angeline M., et al.
Publicado: (2011)

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains
por: Abrami, Laurence, et al.
Publicado: (2021)

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH
por: Lu, Yingying, et al.
Publicado: (2013)

Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH
Publicado: (1989)

Lysosomal pH and analysis of the counter ion pathways that support acidification
por: DiCiccio, Jessica E., et al.
Publicado: (2011)

Bioimaging of Lysosomes with a BODIPY pH-Dependent Fluorescent Probe
por: Gonçalves, Raquel C. R., et al.
Publicado: (2022)

Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism
por: Breiden, Bernadette, et al.
Publicado: (2021)

Engineering a nanolab for the determination of lysosomal nitric oxide by the rational design of a pH-activatable fluorescent probe
por: Li, Yinhui, et al.
Publicado: (2016)

Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells
por: Baltazar, Gabriel C., et al.
Publicado: (2012)

Natural variation in acyl editing is a determinant of seed storage oil composition
por: Menard, Guillaume N., et al.
Publicado: (2018)

Cardiac Hypertrophy in Mice with Long-Chain Acyl-CoA Dehydrogenase (LCAD) or Very Long-Chain Acyl-CoA Dehydrogenase (VLCAD) Deficiency
por: Cox, Keith B., et al.
Publicado: (2009)

A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands
por: Mottillo, Emilio P., et al.
Publicado: (2023)

STAT3 associates with vacuolar H(+)-ATPase and regulates cytosolic and lysosomal pH
por: Liu, Bin, et al.
Publicado: (2018)

Bioorthogonal pro-metabolites for profiling short chain fatty acylation
por: Sinclair, Wilson R., et al.
Publicado: (2017)

Full-Length Gα(q)–Phospholipase C-β3 Structure Reveals Interfaces of the C-terminal Coiled-Coil Domain
por: Lyon, Angeline M., et al.
Publicado: (2013)

Oxidation of Low-Density Lipoprotein by Iron at Lysosomal pH: Implications for Atherosclerosis
por: Satchell, Leanne, et al.
Publicado: (2012)

Rhodamine-Based Cyclic Hydroxamate as Fluorescent pH Probe for Imaging of Lysosomes
por: Kim, Young Ju, et al.
Publicado: (2023)

Glucosylceramide acyl chain length is sensed by the glycolipid transfer protein
por: Backman, Anders P. E., et al.
Publicado: (2018)

Acyl Chain Length of Phosphatidylserine Is Correlated with Plant Lifespan
por: Li, Yan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_i423pgf3kojkmmu46dffn5hma4