Cargando…
Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia
BACKGROUND: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder, with a strong genetic component. Previous research has shown that medial temporal lobe atrophy is a common feature of FTD. However, no study has so far investigated the differential vulnerability of the hippocam...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027942/ https://www.ncbi.nlm.nih.gov/pubmed/29889066 http://dx.doi.org/10.3233/JAD-180195 |
_version_ | 1783336696871387136 |
---|---|
author | Bocchetta, Martina Iglesias, Juan Eugenio Scelsi, Marzia A. Cash, David M. Cardoso, M. Jorge Modat, Marc Altmann, Andre Ourselin, Sebastien Warren, Jason D. Rohrer, Jonathan D. |
author_facet | Bocchetta, Martina Iglesias, Juan Eugenio Scelsi, Marzia A. Cash, David M. Cardoso, M. Jorge Modat, Marc Altmann, Andre Ourselin, Sebastien Warren, Jason D. Rohrer, Jonathan D. |
author_sort | Bocchetta, Martina |
collection | PubMed |
description | BACKGROUND: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder, with a strong genetic component. Previous research has shown that medial temporal lobe atrophy is a common feature of FTD. However, no study has so far investigated the differential vulnerability of the hippocampal subfields in FTD. OBJECTIVES: We aimed to investigate hippocampal subfield volumes in genetic FTD. METHODS: We in6/2/2018vestigated hippocampal subfield volumes in a cohort of 75 patients with genetic FTD (age: mean (standard deviation) 59.3 (7.7) years; disease duration: 5.1 (3.4) years; 29 with MAPT, 28 with C9orf72, and 18 with GRN mutations) compared with 97 age-matched controls (age: 62.1 (11.1) years). We performed a segmentation of their volumetric T1-weighted MRI scans to extract hippocampal subfields volumes. Left and right volumes were summed and corrected for total intracranial volumes. RESULTS: All three groups had smaller hippocampi than controls. The MAPT group had the most atrophic hippocampi, with the subfields showing the largest difference from controls being CA1-4 (24–27%, p < 0.0005). For C9orf72, the CA4, CA1, and dentate gyrus regions (8–11%, p < 0.0005), and for GRN the presubiculum and subiculum (10–14%, p < 0.0005) showed the largest differences from controls. CONCLUSIONS: The hippocampus was affected in all mutation types but a different pattern of subfield involvement was found in the three genetic groups, consistent with differential cortical-subcortical network vulnerability. |
format | Online Article Text |
id | pubmed-6027942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60279422018-07-05 Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia Bocchetta, Martina Iglesias, Juan Eugenio Scelsi, Marzia A. Cash, David M. Cardoso, M. Jorge Modat, Marc Altmann, Andre Ourselin, Sebastien Warren, Jason D. Rohrer, Jonathan D. J Alzheimers Dis Research Article BACKGROUND: Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder, with a strong genetic component. Previous research has shown that medial temporal lobe atrophy is a common feature of FTD. However, no study has so far investigated the differential vulnerability of the hippocampal subfields in FTD. OBJECTIVES: We aimed to investigate hippocampal subfield volumes in genetic FTD. METHODS: We in6/2/2018vestigated hippocampal subfield volumes in a cohort of 75 patients with genetic FTD (age: mean (standard deviation) 59.3 (7.7) years; disease duration: 5.1 (3.4) years; 29 with MAPT, 28 with C9orf72, and 18 with GRN mutations) compared with 97 age-matched controls (age: 62.1 (11.1) years). We performed a segmentation of their volumetric T1-weighted MRI scans to extract hippocampal subfields volumes. Left and right volumes were summed and corrected for total intracranial volumes. RESULTS: All three groups had smaller hippocampi than controls. The MAPT group had the most atrophic hippocampi, with the subfields showing the largest difference from controls being CA1-4 (24–27%, p < 0.0005). For C9orf72, the CA4, CA1, and dentate gyrus regions (8–11%, p < 0.0005), and for GRN the presubiculum and subiculum (10–14%, p < 0.0005) showed the largest differences from controls. CONCLUSIONS: The hippocampus was affected in all mutation types but a different pattern of subfield involvement was found in the three genetic groups, consistent with differential cortical-subcortical network vulnerability. IOS Press 2018-06-19 /pmc/articles/PMC6027942/ /pubmed/29889066 http://dx.doi.org/10.3233/JAD-180195 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Bocchetta, Martina Iglesias, Juan Eugenio Scelsi, Marzia A. Cash, David M. Cardoso, M. Jorge Modat, Marc Altmann, Andre Ourselin, Sebastien Warren, Jason D. Rohrer, Jonathan D. Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia |
title | Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia |
title_full | Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia |
title_fullStr | Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia |
title_full_unstemmed | Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia |
title_short | Hippocampal Subfield Volumetry: Differential Pattern of Atrophy in Different Forms of Genetic Frontotemporal Dementia |
title_sort | hippocampal subfield volumetry: differential pattern of atrophy in different forms of genetic frontotemporal dementia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027942/ https://www.ncbi.nlm.nih.gov/pubmed/29889066 http://dx.doi.org/10.3233/JAD-180195 |
work_keys_str_mv | AT bocchettamartina hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT iglesiasjuaneugenio hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT scelsimarziaa hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT cashdavidm hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT cardosomjorge hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT modatmarc hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT altmannandre hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT ourselinsebastien hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT warrenjasond hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia AT rohrerjonathand hippocampalsubfieldvolumetrydifferentialpatternofatrophyindifferentformsofgeneticfrontotemporaldementia |