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The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases
Biochemical, structural, and cellular studies reveal Jumonji-C (JmjC) domain-containing 7 (JMJD7) as a 2-oxoglutarate (2OG)-dependent oxygenase catalyzing a previously unreported type of post-translational modification, (3S)-lysyl hydroxylation. Crystallographic analyses reveal JMJD7 as more closely...
Autores principales: | Markolovic, Suzana, Zhuang, Qinqin, Wilkins, Sarah E, Eaton, Charlotte D, Abboud, Martine I, Katz, Maximiliano J, McNeil, Helen E, Leśniak, Robert K, Hall, Charlotte, Struwe, Weston B, Konietzny, Rebecca, Davis, Simon, Yang, Ming, Ge, Wei, Benesch, Justin LP, Kessler, Benedikt M, Ratcliffe, Peter J, Cockman, Matthew E, Fischer, Roman, Wappner, Pablo, Chowdhury, Rasheduzzaman, Coleman, Mathew L, Schofield, Christopher J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027965/ https://www.ncbi.nlm.nih.gov/pubmed/29915238 http://dx.doi.org/10.1038/s41589-018-0071-y |
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