Cargando…

Serum uric acid and arterial hypertension—Data from Sephar III survey

OBJECTIVES: This paper aims to evaluate the association between serum uric acid (SUA) levels, arterial hypertension (HT) prevalence, blood pressure values control, kidney function and intima media thickness (IMT), as a surrogate marker of early atherosclerosis, in a representative group of Romanian...

Descripción completa

Detalles Bibliográficos
Autores principales: Buzas, Roxana, Tautu, Oana-Florentina, Dorobantu, Maria, Ivan, Vlad, Lighezan, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028095/
https://www.ncbi.nlm.nih.gov/pubmed/29966019
http://dx.doi.org/10.1371/journal.pone.0199865
_version_ 1783336710412697600
author Buzas, Roxana
Tautu, Oana-Florentina
Dorobantu, Maria
Ivan, Vlad
Lighezan, Daniel
author_facet Buzas, Roxana
Tautu, Oana-Florentina
Dorobantu, Maria
Ivan, Vlad
Lighezan, Daniel
author_sort Buzas, Roxana
collection PubMed
description OBJECTIVES: This paper aims to evaluate the association between serum uric acid (SUA) levels, arterial hypertension (HT) prevalence, blood pressure values control, kidney function and intima media thickness (IMT), as a surrogate marker of early atherosclerosis, in a representative group of Romanian adult population. MATERIALS AND METHODS: The study sample consists in 1920 adults included in SEPHAR III (Study for the Evaluation of Prevalence of Hypertension and cArdiovascular Risk in Romania) survey (mean age 48.63 years, 52.76% females) collecting data for SUA levels, blood pressure (BP) measurements, kidney function by estimated glomerular filtration rate (eGFR) and carotid IMT. SUA levels between 2,40–5,70mg/dl in females and 3,40–7,00mg/dl in males respectively were considered normal. HT and HT control were defined according to the current guidelines. IMT evaluation was assessed by B-mode Doppler ultrasound evaluation. RESULTS: Hypertensive subjects had significantly higher values of SUA compared with normotensive subjects, hypertensive patients were 1.713 times more likely to have higher values of SUA. Among treated hypertensive patients, those without optimal BP control had significantly higher SUA levels compared with those with optimal BP control, the presence of hyperuricemia increasing the odds of suboptimal BP control by 1.023. Hyperuricemic subjects had significantly lower eGFR values compared with normouricemic ones, on an average with 14.28ml/min/1.73m2 by Modification of Diet in Renal Disease formula (MDRD) and with 16.64ml/min/1.73m2 by Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI), with an indirect association between SUA levels and eGFR values (rs = -0.319 / -0.347), independent of age. IMT values recorded in hyperuricemic subjects were significantly increased, on an average with 0.08mm, compared with normouricemic subjects, with a direct association between SUA levels and IMT values (rs = 0.263), independent of BP values. CONCLUSION: The results of our study offers support that increased SUA levels are associated with arterial hypertension and with suboptimal BP control in treated hypertensive subjects. The decline in kidney function, independent of age, and also increased IMT values as a marker of atherosclerosis, were also correlated with elevated SUA values. Hyperuricemia screening may have a role in identifying patients at risk of developing HT and lowering SUA levels may improve not only BP control in treated HT patients but also decrease total cardiovascular mortality by slowing the progression of atherosclerosis and renal failure in hypertensive patients.
format Online
Article
Text
id pubmed-6028095
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-60280952018-07-19 Serum uric acid and arterial hypertension—Data from Sephar III survey Buzas, Roxana Tautu, Oana-Florentina Dorobantu, Maria Ivan, Vlad Lighezan, Daniel PLoS One Research Article OBJECTIVES: This paper aims to evaluate the association between serum uric acid (SUA) levels, arterial hypertension (HT) prevalence, blood pressure values control, kidney function and intima media thickness (IMT), as a surrogate marker of early atherosclerosis, in a representative group of Romanian adult population. MATERIALS AND METHODS: The study sample consists in 1920 adults included in SEPHAR III (Study for the Evaluation of Prevalence of Hypertension and cArdiovascular Risk in Romania) survey (mean age 48.63 years, 52.76% females) collecting data for SUA levels, blood pressure (BP) measurements, kidney function by estimated glomerular filtration rate (eGFR) and carotid IMT. SUA levels between 2,40–5,70mg/dl in females and 3,40–7,00mg/dl in males respectively were considered normal. HT and HT control were defined according to the current guidelines. IMT evaluation was assessed by B-mode Doppler ultrasound evaluation. RESULTS: Hypertensive subjects had significantly higher values of SUA compared with normotensive subjects, hypertensive patients were 1.713 times more likely to have higher values of SUA. Among treated hypertensive patients, those without optimal BP control had significantly higher SUA levels compared with those with optimal BP control, the presence of hyperuricemia increasing the odds of suboptimal BP control by 1.023. Hyperuricemic subjects had significantly lower eGFR values compared with normouricemic ones, on an average with 14.28ml/min/1.73m2 by Modification of Diet in Renal Disease formula (MDRD) and with 16.64ml/min/1.73m2 by Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI), with an indirect association between SUA levels and eGFR values (rs = -0.319 / -0.347), independent of age. IMT values recorded in hyperuricemic subjects were significantly increased, on an average with 0.08mm, compared with normouricemic subjects, with a direct association between SUA levels and IMT values (rs = 0.263), independent of BP values. CONCLUSION: The results of our study offers support that increased SUA levels are associated with arterial hypertension and with suboptimal BP control in treated hypertensive subjects. The decline in kidney function, independent of age, and also increased IMT values as a marker of atherosclerosis, were also correlated with elevated SUA values. Hyperuricemia screening may have a role in identifying patients at risk of developing HT and lowering SUA levels may improve not only BP control in treated HT patients but also decrease total cardiovascular mortality by slowing the progression of atherosclerosis and renal failure in hypertensive patients. Public Library of Science 2018-07-02 /pmc/articles/PMC6028095/ /pubmed/29966019 http://dx.doi.org/10.1371/journal.pone.0199865 Text en © 2018 Buzas et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Buzas, Roxana
Tautu, Oana-Florentina
Dorobantu, Maria
Ivan, Vlad
Lighezan, Daniel
Serum uric acid and arterial hypertension—Data from Sephar III survey
title Serum uric acid and arterial hypertension—Data from Sephar III survey
title_full Serum uric acid and arterial hypertension—Data from Sephar III survey
title_fullStr Serum uric acid and arterial hypertension—Data from Sephar III survey
title_full_unstemmed Serum uric acid and arterial hypertension—Data from Sephar III survey
title_short Serum uric acid and arterial hypertension—Data from Sephar III survey
title_sort serum uric acid and arterial hypertension—data from sephar iii survey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028095/
https://www.ncbi.nlm.nih.gov/pubmed/29966019
http://dx.doi.org/10.1371/journal.pone.0199865
work_keys_str_mv AT buzasroxana serumuricacidandarterialhypertensiondatafromsephariiisurvey
AT tautuoanaflorentina serumuricacidandarterialhypertensiondatafromsephariiisurvey
AT dorobantumaria serumuricacidandarterialhypertensiondatafromsephariiisurvey
AT ivanvlad serumuricacidandarterialhypertensiondatafromsephariiisurvey
AT lighezandaniel serumuricacidandarterialhypertensiondatafromsephariiisurvey