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Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction

Early postnatal-life malnutrition remains prevalent globally, and about 45% of all child deaths are linked to malnutrition. It is not clear whether survivors of childhood malnutrition suffer from long-term metabolic effects, especially when they are later in life exposed to a fat and carbohydrate ri...

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Autores principales: Dalvi, Prasad S., Yang, Steven, Swain, Nathan, Kim, Junsoo, Saha, Senjuti, Bourdon, Celine, Zhang, Ling, Chami, Rose, Bandsma, Robert H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028108/
https://www.ncbi.nlm.nih.gov/pubmed/29965973
http://dx.doi.org/10.1371/journal.pone.0199916
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author Dalvi, Prasad S.
Yang, Steven
Swain, Nathan
Kim, Junsoo
Saha, Senjuti
Bourdon, Celine
Zhang, Ling
Chami, Rose
Bandsma, Robert H. J.
author_facet Dalvi, Prasad S.
Yang, Steven
Swain, Nathan
Kim, Junsoo
Saha, Senjuti
Bourdon, Celine
Zhang, Ling
Chami, Rose
Bandsma, Robert H. J.
author_sort Dalvi, Prasad S.
collection PubMed
description Early postnatal-life malnutrition remains prevalent globally, and about 45% of all child deaths are linked to malnutrition. It is not clear whether survivors of childhood malnutrition suffer from long-term metabolic effects, especially when they are later in life exposed to a fat and carbohydrate rich obesogenic diet. The lack of knowledge around this dietary “double burden” warrants studies to understand the long-term consequences of children previously exposed to malnutrition. We hypothesized that an early-life nutritional insult of low protein consumption in mice would lead to long-term metabolic disturbances that would exacerbate the development of diet-induced insulin resistance and non-alcoholic fatty liver disease (NAFLD). We investigated the effects of feeding a low protein diet (4% wt/wt) immediately after weaning for four weeks and subsequent feeding of a high carbohydrate high fat feeding for 16 weeks on metabolic function and development of NAFLD. Mice exposed to early-life protein restriction demonstrated a transient glucose intolerance upon recovery by regular chow diet feeding. However, protein restriction after weaning in mice did not exacerbate an obesogenic diet-induced insulin resistance or progression to NAFLD. These data suggest that transient protein restriction in early-life does not exacerbate an obesogenic diet-induced NAFLD and insulin resistance.
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spelling pubmed-60281082018-07-19 Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction Dalvi, Prasad S. Yang, Steven Swain, Nathan Kim, Junsoo Saha, Senjuti Bourdon, Celine Zhang, Ling Chami, Rose Bandsma, Robert H. J. PLoS One Research Article Early postnatal-life malnutrition remains prevalent globally, and about 45% of all child deaths are linked to malnutrition. It is not clear whether survivors of childhood malnutrition suffer from long-term metabolic effects, especially when they are later in life exposed to a fat and carbohydrate rich obesogenic diet. The lack of knowledge around this dietary “double burden” warrants studies to understand the long-term consequences of children previously exposed to malnutrition. We hypothesized that an early-life nutritional insult of low protein consumption in mice would lead to long-term metabolic disturbances that would exacerbate the development of diet-induced insulin resistance and non-alcoholic fatty liver disease (NAFLD). We investigated the effects of feeding a low protein diet (4% wt/wt) immediately after weaning for four weeks and subsequent feeding of a high carbohydrate high fat feeding for 16 weeks on metabolic function and development of NAFLD. Mice exposed to early-life protein restriction demonstrated a transient glucose intolerance upon recovery by regular chow diet feeding. However, protein restriction after weaning in mice did not exacerbate an obesogenic diet-induced insulin resistance or progression to NAFLD. These data suggest that transient protein restriction in early-life does not exacerbate an obesogenic diet-induced NAFLD and insulin resistance. Public Library of Science 2018-07-02 /pmc/articles/PMC6028108/ /pubmed/29965973 http://dx.doi.org/10.1371/journal.pone.0199916 Text en © 2018 Dalvi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Dalvi, Prasad S.
Yang, Steven
Swain, Nathan
Kim, Junsoo
Saha, Senjuti
Bourdon, Celine
Zhang, Ling
Chami, Rose
Bandsma, Robert H. J.
Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction
title Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction
title_full Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction
title_fullStr Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction
title_full_unstemmed Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction
title_short Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction
title_sort long-term metabolic effects of malnutrition: liver steatosis and insulin resistance following early-life protein restriction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028108/
https://www.ncbi.nlm.nih.gov/pubmed/29965973
http://dx.doi.org/10.1371/journal.pone.0199916
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