Gene expression in the corneal endothelium of Fuchs endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4

Fuchs Endothelial Corneal Dystrophy (FECD) is a late onset, autosomal dominant eye disease that can lead to loss of vision. Expansion of a CTG trinucleotide repeat in the third intron of the transcription factor 4 (TCF4) gene is highly associated with FECD. However, only about 75% of FECD patients i...

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Detalles Bibliográficos
Autores principales: Wieben, Eric D., Aleff, Ross A., Tang, Xiaojia, Kalari, Krishna R., Maguire, Leo J., Patel, Sanjay V., Baratz, Keith H., Fautsch, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028112/
https://www.ncbi.nlm.nih.gov/pubmed/29966009
http://dx.doi.org/10.1371/journal.pone.0200005

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