Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach

BACKGROUND: Adjuvants have the potential to increase the efficacy of protein-based vaccines but need to be maintained within specific temperature and storage conditions. Lyophilization can be used to increase the thermostability of protein pharmaceuticals; however, no marketed vaccine that contains...

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Detalles Bibliográficos
Autores principales: Kramer, Ryan M, Archer, Michelle C, Orr, Mark T, Dubois Cauwelaert, Natasha, Beebe, Elyse A, Huang, Po-wei D, Dowling, Quinton M, Schwartz, Alicia M, Fedor, Dawn M, Vedvick, Thomas S, Fox, Christopher B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028350/
https://www.ncbi.nlm.nih.gov/pubmed/29983563
http://dx.doi.org/10.2147/IJN.S159839

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