Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess

Treatment of Pseudomonas aeruginosa remains challenging, despite the availability ceftolozane‐tazobactam. We report a treatment failure with ceftolozane‐tazobactam salvage therapy for pneumonia complicated by lung abscess. Drug resistance, dose selection, and source control are possible contributing...

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Detalles Bibliográficos
Autores principales: Lewis, Paul O., Cluck, David B., Tharp, Jennifer L., Krolikowski, Matthew A., Patel, Paras D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028400/
https://www.ncbi.nlm.nih.gov/pubmed/29988582
http://dx.doi.org/10.1002/ccr3.1612
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author Lewis, Paul O.
Cluck, David B.
Tharp, Jennifer L.
Krolikowski, Matthew A.
Patel, Paras D.
author_facet Lewis, Paul O.
Cluck, David B.
Tharp, Jennifer L.
Krolikowski, Matthew A.
Patel, Paras D.
author_sort Lewis, Paul O.
collection PubMed
description Treatment of Pseudomonas aeruginosa remains challenging, despite the availability ceftolozane‐tazobactam. We report a treatment failure with ceftolozane‐tazobactam salvage therapy for pneumonia complicated by lung abscess. Drug resistance, dose selection, and source control are possible contributing factors. Ceftolozane‐tazobactam susceptibility testing should precede therapy and consideration should be given to dosing selection.
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spelling pubmed-60284002018-07-09 Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess Lewis, Paul O. Cluck, David B. Tharp, Jennifer L. Krolikowski, Matthew A. Patel, Paras D. Clin Case Rep Case Reports Treatment of Pseudomonas aeruginosa remains challenging, despite the availability ceftolozane‐tazobactam. We report a treatment failure with ceftolozane‐tazobactam salvage therapy for pneumonia complicated by lung abscess. Drug resistance, dose selection, and source control are possible contributing factors. Ceftolozane‐tazobactam susceptibility testing should precede therapy and consideration should be given to dosing selection. John Wiley and Sons Inc. 2018-05-28 /pmc/articles/PMC6028400/ /pubmed/29988582 http://dx.doi.org/10.1002/ccr3.1612 Text en © 2018 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Lewis, Paul O.
Cluck, David B.
Tharp, Jennifer L.
Krolikowski, Matthew A.
Patel, Paras D.
Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess
title Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess
title_full Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess
title_fullStr Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess
title_full_unstemmed Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess
title_short Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess
title_sort failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028400/
https://www.ncbi.nlm.nih.gov/pubmed/29988582
http://dx.doi.org/10.1002/ccr3.1612
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