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Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder
PURPOSE: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation. MATERIALS AND METHODS:...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Urological Association
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028472/ https://www.ncbi.nlm.nih.gov/pubmed/29984340 http://dx.doi.org/10.4111/icu.2018.59.4.252 |
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author | Dokumacioglu, Eda Demiray, Ozay Dokumacioglu, Ali Sahin, Arzu Sen, Tugba Mazlum Cankaya, Soner |
author_facet | Dokumacioglu, Eda Demiray, Ozay Dokumacioglu, Ali Sahin, Arzu Sen, Tugba Mazlum Cankaya, Soner |
author_sort | Dokumacioglu, Eda |
collection | PubMed |
description | PURPOSE: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation. MATERIALS AND METHODS: A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease. Levels of MDA and 8-OHdG were measured in 24-hour urine samples for all subjects. RESULTS: Urinary levels of MDA and 8-OHdG were significantly higher in the OAB group than in the control group (p<0.001). A significant positive correlation (p<0.001) was found between the measurements of 8-OHdG and MDA. CONCLUSIONS: Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are needed. |
format | Online Article Text |
id | pubmed-6028472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Urological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-60284722018-07-07 Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder Dokumacioglu, Eda Demiray, Ozay Dokumacioglu, Ali Sahin, Arzu Sen, Tugba Mazlum Cankaya, Soner Investig Clin Urol Original Article PURPOSE: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation. MATERIALS AND METHODS: A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease. Levels of MDA and 8-OHdG were measured in 24-hour urine samples for all subjects. RESULTS: Urinary levels of MDA and 8-OHdG were significantly higher in the OAB group than in the control group (p<0.001). A significant positive correlation (p<0.001) was found between the measurements of 8-OHdG and MDA. CONCLUSIONS: Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are needed. The Korean Urological Association 2018-07 2018-06-14 /pmc/articles/PMC6028472/ /pubmed/29984340 http://dx.doi.org/10.4111/icu.2018.59.4.252 Text en © The Korean Urological Association, 2018 http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dokumacioglu, Eda Demiray, Ozay Dokumacioglu, Ali Sahin, Arzu Sen, Tugba Mazlum Cankaya, Soner Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder |
title | Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder |
title_full | Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder |
title_fullStr | Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder |
title_full_unstemmed | Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder |
title_short | Measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder |
title_sort | measuring urinary 8-hydroxy-2′-deoxyguanosine and malondialdehyde levels in women with overactive bladder |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028472/ https://www.ncbi.nlm.nih.gov/pubmed/29984340 http://dx.doi.org/10.4111/icu.2018.59.4.252 |
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