Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

Preservation of bone mass is crucial for healthy ageing and largely depends on adequate responses of matrix-embedded osteocytes. These cells control bone formation and resorption concurrently by secreting the WNT/β-catenin antagonist sclerostin (SOST). Osteocytes reside within a low oxygen microenvi...

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Detalles Bibliográficos
Autores principales: Stegen, Steve, Stockmans, Ingrid, Moermans, Karen, Thienpont, Bernard, Maxwell, Patrick H., Carmeliet, Peter, Carmeliet, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028485/
https://www.ncbi.nlm.nih.gov/pubmed/29967369
http://dx.doi.org/10.1038/s41467-018-04679-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028485/
https://www.ncbi.nlm.nih.gov/pubmed/29967369
http://dx.doi.org/10.1038/s41467-018-04679-7

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