Regulating the regulator: Bhlhe40 directly keeps IL-10 in check

In this issue of JEM, two complementary manuscripts by Huynh et al. (https://doi.org/10.1084/jem.20171704) and Yu et al. (https://doi.org/10.1084/jem.20170155) demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with Mycobacterium tuberculosis o...

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Detalles Bibliográficos
Autores principales: Gabryšová, Leona, O’Garra, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028514/
https://www.ncbi.nlm.nih.gov/pubmed/29880485
http://dx.doi.org/10.1084/jem.20180824
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author Gabryšová, Leona
O’Garra, Anne
author_facet Gabryšová, Leona
O’Garra, Anne
author_sort Gabryšová, Leona
collection PubMed
description In this issue of JEM, two complementary manuscripts by Huynh et al. (https://doi.org/10.1084/jem.20171704) and Yu et al. (https://doi.org/10.1084/jem.20170155) demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with Mycobacterium tuberculosis or Toxoplasma gondii. Deletion of Bhlhe40 in both cases resulted in chronic infection and increased pathogen load as a consequence of increased IL-10 production.
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spelling pubmed-60285142019-01-02 Regulating the regulator: Bhlhe40 directly keeps IL-10 in check Gabryšová, Leona O’Garra, Anne J Exp Med News In this issue of JEM, two complementary manuscripts by Huynh et al. (https://doi.org/10.1084/jem.20171704) and Yu et al. (https://doi.org/10.1084/jem.20170155) demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with Mycobacterium tuberculosis or Toxoplasma gondii. Deletion of Bhlhe40 in both cases resulted in chronic infection and increased pathogen load as a consequence of increased IL-10 production. Rockefeller University Press 2018-07-02 /pmc/articles/PMC6028514/ /pubmed/29880485 http://dx.doi.org/10.1084/jem.20180824 Text en © 2018 Gabryšová and O'Garra http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Gabryšová, Leona
O’Garra, Anne
Regulating the regulator: Bhlhe40 directly keeps IL-10 in check
title Regulating the regulator: Bhlhe40 directly keeps IL-10 in check
title_full Regulating the regulator: Bhlhe40 directly keeps IL-10 in check
title_fullStr Regulating the regulator: Bhlhe40 directly keeps IL-10 in check
title_full_unstemmed Regulating the regulator: Bhlhe40 directly keeps IL-10 in check
title_short Regulating the regulator: Bhlhe40 directly keeps IL-10 in check
title_sort regulating the regulator: bhlhe40 directly keeps il-10 in check
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028514/
https://www.ncbi.nlm.nih.gov/pubmed/29880485
http://dx.doi.org/10.1084/jem.20180824
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