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PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation

B lymphocytes use B cell receptors (BCRs) to sense the chemical and physical features of antigens. The activation of isotype-switched IgG-BCR by mechanical force exhibits a distinct sensitivity and threshold in comparison with IgM-BCR. However, molecular mechanisms governing these differences remain...

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Detalles Bibliográficos
Autores principales:	Wan, Zhengpeng, Xu, Chenguang, Chen, Xiangjun, Xie, Hengyi, Li, Zongyu, Wang, Jing, Ji, Xingyu, Chen, Haodong, Ji, Qinghua, Shaheen, Samina, Xu, Yang, Wang, Fei, Tang, Zhuo, Zheng, Ji-Shen, Chen, Wei, Lou, Jizhong, Liu, Wanli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028545/ https://www.ncbi.nlm.nih.gov/pubmed/29685902 http://dx.doi.org/10.1083/jcb.201711055

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