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Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity

Tetrahydropyrazino-annelated theophylline (1,3-dimethylxanthine) derivatives have previously been shown to display increased water-solubility as compared to the parent xanthines due to their basic character. In the present study, we modified this promising scaffold by replacing the 1,3-dimethyl resi...

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Detalles Bibliográficos
Autores principales:	Koch, Pierre, Brunschweiger, Andreas, Namasivayam, Vigneshwaran, Ullrich, Stefan, Maruca, Annalisa, Lazzaretto, Beatrice, Küppers, Petra, Hinz, Sonja, Hockemeyer, Jörg, Wiese, Michael, Heer, Jag, Alcaro, Stefano, Kiec-Kononowicz, Katarzyna, Müller, Christa E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028563/ https://www.ncbi.nlm.nih.gov/pubmed/29998095 http://dx.doi.org/10.3389/fchem.2018.00206

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