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Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation
In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028595/ https://www.ncbi.nlm.nih.gov/pubmed/29997473 http://dx.doi.org/10.3389/fnins.2018.00427 |
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author | Cocco, Sara Podda, Maria V. Grassi, Claudio |
author_facet | Cocco, Sara Podda, Maria V. Grassi, Claudio |
author_sort | Cocco, Sara |
collection | PubMed |
description | In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well as in neurological and neurodegenerative disorders, including Alzheimer’s disease (AD). In this scenario, non-invasive techniques for memory enhancement, such as tDCS, are receiving increasing attention. The knowledge of molecular mechanisms subtending tDCS effects is of pivotal importance for a more rationale use of this technique in clinical settings. Although we are still far from having a clear picture, recent literature on human and animal studies has pointed to the involvement of synaptic plasticity mechanisms in mediating tDCS effects on long-term memory. Here we review these studies focusing on the neurotrophin “brain-derived neurotrophic factor” (BDNF) as critical tDCS effector. |
format | Online Article Text |
id | pubmed-6028595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60285952018-07-11 Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation Cocco, Sara Podda, Maria V. Grassi, Claudio Front Neurosci Neuroscience In the recent years numerous studies have provided encouraging results supporting the use of transcranial direct current stimulation (tDCS) as non-invasive brain stimulation technique to improve motor and cognitive functions in patients suffering from neurological and neuropsychiatric disorders as well as in healthy subjects. Among the multiple effects elicited by tDCS on cognitive functions, experimental evidence and clinical findings have highlighted the beneficial impact on long-term memory. Memory deficits occur during physiological aging as well as in neurological and neurodegenerative disorders, including Alzheimer’s disease (AD). In this scenario, non-invasive techniques for memory enhancement, such as tDCS, are receiving increasing attention. The knowledge of molecular mechanisms subtending tDCS effects is of pivotal importance for a more rationale use of this technique in clinical settings. Although we are still far from having a clear picture, recent literature on human and animal studies has pointed to the involvement of synaptic plasticity mechanisms in mediating tDCS effects on long-term memory. Here we review these studies focusing on the neurotrophin “brain-derived neurotrophic factor” (BDNF) as critical tDCS effector. Frontiers Media S.A. 2018-06-26 /pmc/articles/PMC6028595/ /pubmed/29997473 http://dx.doi.org/10.3389/fnins.2018.00427 Text en Copyright © 2018 Cocco, Podda and Grassi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Cocco, Sara Podda, Maria V. Grassi, Claudio Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation |
title | Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation |
title_full | Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation |
title_fullStr | Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation |
title_full_unstemmed | Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation |
title_short | Role of BDNF Signaling in Memory Enhancement Induced by Transcranial Direct Current Stimulation |
title_sort | role of bdnf signaling in memory enhancement induced by transcranial direct current stimulation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028595/ https://www.ncbi.nlm.nih.gov/pubmed/29997473 http://dx.doi.org/10.3389/fnins.2018.00427 |
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