CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer

A 61-year-old woman who had smoked for 41 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin respon...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakajima, Masanori, Uchibori, Ayumi, Ogawa, Yuki, Miyazaki, Tai, Ichikawa, Yaeko, Kaneko, Kimihiko, Takahashi, Toshiyuki, Nakashima, Ichiro, Shiraishi, Hirokazu, Motomura, Masakatsu, Chiba, Atsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028676/
https://www.ncbi.nlm.nih.gov/pubmed/29321433
http://dx.doi.org/10.2169/internalmedicine.9736-17
Descripción
Sumario:A 61-year-old woman who had smoked for 41 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin response mediator protein (CRMP)5 and HuD antibodies in her serum and cerebrospinal fluid. She was diagnosed with paraneoplastic optic neuropathy (PON) accompanied by paraneoplastic opsoclonus-ataxia syndrome. Her symptoms improved after removing the SCLC. Classical PON is rare in Japan. We recommend assaying for CV2/CRMP5 antibodies and searching for cancer in elderly patients with subacute painless visual impairment.

Ejemplares similares