CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer

A 61-year-old woman who had smoked for 41 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin respon...

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Autores principales: Nakajima, Masanori, Uchibori, Ayumi, Ogawa, Yuki, Miyazaki, Tai, Ichikawa, Yaeko, Kaneko, Kimihiko, Takahashi, Toshiyuki, Nakashima, Ichiro, Shiraishi, Hirokazu, Motomura, Masakatsu, Chiba, Atsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028676/
https://www.ncbi.nlm.nih.gov/pubmed/29321433
http://dx.doi.org/10.2169/internalmedicine.9736-17
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author Nakajima, Masanori
Uchibori, Ayumi
Ogawa, Yuki
Miyazaki, Tai
Ichikawa, Yaeko
Kaneko, Kimihiko
Takahashi, Toshiyuki
Nakashima, Ichiro
Shiraishi, Hirokazu
Motomura, Masakatsu
Chiba, Atsuro
author_facet Nakajima, Masanori
Uchibori, Ayumi
Ogawa, Yuki
Miyazaki, Tai
Ichikawa, Yaeko
Kaneko, Kimihiko
Takahashi, Toshiyuki
Nakashima, Ichiro
Shiraishi, Hirokazu
Motomura, Masakatsu
Chiba, Atsuro
author_sort Nakajima, Masanori
collection PubMed
description A 61-year-old woman who had smoked for 41 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin response mediator protein (CRMP)5 and HuD antibodies in her serum and cerebrospinal fluid. She was diagnosed with paraneoplastic optic neuropathy (PON) accompanied by paraneoplastic opsoclonus-ataxia syndrome. Her symptoms improved after removing the SCLC. Classical PON is rare in Japan. We recommend assaying for CV2/CRMP5 antibodies and searching for cancer in elderly patients with subacute painless visual impairment.
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spelling pubmed-60286762018-07-03 CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer Nakajima, Masanori Uchibori, Ayumi Ogawa, Yuki Miyazaki, Tai Ichikawa, Yaeko Kaneko, Kimihiko Takahashi, Toshiyuki Nakashima, Ichiro Shiraishi, Hirokazu Motomura, Masakatsu Chiba, Atsuro Intern Med Case Report A 61-year-old woman who had smoked for 41 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin response mediator protein (CRMP)5 and HuD antibodies in her serum and cerebrospinal fluid. She was diagnosed with paraneoplastic optic neuropathy (PON) accompanied by paraneoplastic opsoclonus-ataxia syndrome. Her symptoms improved after removing the SCLC. Classical PON is rare in Japan. We recommend assaying for CV2/CRMP5 antibodies and searching for cancer in elderly patients with subacute painless visual impairment. The Japanese Society of Internal Medicine 2018-01-11 2018-06-01 /pmc/articles/PMC6028676/ /pubmed/29321433 http://dx.doi.org/10.2169/internalmedicine.9736-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakajima, Masanori
Uchibori, Ayumi
Ogawa, Yuki
Miyazaki, Tai
Ichikawa, Yaeko
Kaneko, Kimihiko
Takahashi, Toshiyuki
Nakashima, Ichiro
Shiraishi, Hirokazu
Motomura, Masakatsu
Chiba, Atsuro
CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer
title CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer
title_full CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer
title_fullStr CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer
title_full_unstemmed CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer
title_short CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer
title_sort cv2/crmp5-antibody-related paraneoplastic optic neuropathy associated with small-cell lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028676/
https://www.ncbi.nlm.nih.gov/pubmed/29321433
http://dx.doi.org/10.2169/internalmedicine.9736-17
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