Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb

Seven new dianthrone glycosides, named polygonumnolides A1–B3 (1–7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and m...

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Autores principales: Yang, Jianbo, Yan, Zheng, Ren, Jin, Dai, Zhong, Ma, Shuangcheng, Wang, Aiguo, Su, Yalun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pharmaceutical Society of Korea 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028828/
https://www.ncbi.nlm.nih.gov/pubmed/28681348
http://dx.doi.org/10.1007/s12272-016-0816-7
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author Yang, Jianbo
Yan, Zheng
Ren, Jin
Dai, Zhong
Ma, Shuangcheng
Wang, Aiguo
Su, Yalun
author_facet Yang, Jianbo
Yan, Zheng
Ren, Jin
Dai, Zhong
Ma, Shuangcheng
Wang, Aiguo
Su, Yalun
author_sort Yang, Jianbo
collection PubMed
description Seven new dianthrone glycosides, named polygonumnolides A1–B3 (1–7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1–4 showed moderate cytotoxicity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12272-016-0816-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-60288282018-07-23 Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb Yang, Jianbo Yan, Zheng Ren, Jin Dai, Zhong Ma, Shuangcheng Wang, Aiguo Su, Yalun Arch Pharm Res Research Article Seven new dianthrone glycosides, named polygonumnolides A1–B3 (1–7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1–4 showed moderate cytotoxicity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12272-016-0816-7) contains supplementary material, which is available to authorized users. Pharmaceutical Society of Korea 2017-07-05 2018 /pmc/articles/PMC6028828/ /pubmed/28681348 http://dx.doi.org/10.1007/s12272-016-0816-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Yang, Jianbo
Yan, Zheng
Ren, Jin
Dai, Zhong
Ma, Shuangcheng
Wang, Aiguo
Su, Yalun
Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
title Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
title_full Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
title_fullStr Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
title_full_unstemmed Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
title_short Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb
title_sort polygonumnolides a1–b3, minor dianthrone derivatives from the roots of polygonum multiflorum thunb
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028828/
https://www.ncbi.nlm.nih.gov/pubmed/28681348
http://dx.doi.org/10.1007/s12272-016-0816-7
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