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Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin

BACKGROUND: The early hours after an acute stroke are crucial; early accurate prediction of outcome in stroke patients can help health system providers and families to choose appropriate lines of management and plan for the future. The aim of this work is to assess the role of hemorheological parame...

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Autores principales: Hashem, Saher S., Helmy, Sadek M., El-Fayomy, Nervana M., Oraby, Mohammed I., Menshawy, Mohammed, Dawood, Nermin A., Hashem, Heba S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028876/
https://www.ncbi.nlm.nih.gov/pubmed/30046235
http://dx.doi.org/10.1186/s41983-018-0019-x
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author Hashem, Saher S.
Helmy, Sadek M.
El-Fayomy, Nervana M.
Oraby, Mohammed I.
Menshawy, Mohammed
Dawood, Nermin A.
Hashem, Heba S.
author_facet Hashem, Saher S.
Helmy, Sadek M.
El-Fayomy, Nervana M.
Oraby, Mohammed I.
Menshawy, Mohammed
Dawood, Nermin A.
Hashem, Heba S.
author_sort Hashem, Saher S.
collection PubMed
description BACKGROUND: The early hours after an acute stroke are crucial; early accurate prediction of outcome in stroke patients can help health system providers and families to choose appropriate lines of management and plan for the future. The aim of this work is to assess the role of hemorheological parameters (such as blood viscosity, hematocrit, platelet aggregation, and leukocyte count), protein C, protein S, antithrombin III, and serum albumin as predictors of stroke outcome. METHODS: Thirty subjects, 20 patients with acute ischemic stroke within 24 h from the onset and 10 normal subjects, were included in this case control study. Clinical, functional, and radiological evaluation was done for the patients, and all patients and control were subjected to routine laboratory tests and assessment of blood viscosity, hematocrit level, platelet aggregation, protein C, protein S, and antithrombin III. RESULTS: Platelet aggregation was significantly higher and serum albumin was significantly lower in stroke patients compared to control (p value = 0.000 and 0.039) respectively. On comparing between patient with good and poor outcome, good outcome was associated with increased serum albumin level at admission (p value = 0.03) respectively. A significant negative correlation was found between total leukocyte count, hematocrit value, and stroke outcome (p value = 0.015 and 0.013) respectively. Only albumin was found to be a significant predictor for outcome by linear regression analysis. CONCLUSION: Serum albumin, hematocrit level, and total leukocyte count at the time of presentation of ischemic stroke are useful markers for stroke outcome.
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spelling pubmed-60288762018-07-23 Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin Hashem, Saher S. Helmy, Sadek M. El-Fayomy, Nervana M. Oraby, Mohammed I. Menshawy, Mohammed Dawood, Nermin A. Hashem, Heba S. Egypt J Neurol Psychiatr Neurosurg Research BACKGROUND: The early hours after an acute stroke are crucial; early accurate prediction of outcome in stroke patients can help health system providers and families to choose appropriate lines of management and plan for the future. The aim of this work is to assess the role of hemorheological parameters (such as blood viscosity, hematocrit, platelet aggregation, and leukocyte count), protein C, protein S, antithrombin III, and serum albumin as predictors of stroke outcome. METHODS: Thirty subjects, 20 patients with acute ischemic stroke within 24 h from the onset and 10 normal subjects, were included in this case control study. Clinical, functional, and radiological evaluation was done for the patients, and all patients and control were subjected to routine laboratory tests and assessment of blood viscosity, hematocrit level, platelet aggregation, protein C, protein S, and antithrombin III. RESULTS: Platelet aggregation was significantly higher and serum albumin was significantly lower in stroke patients compared to control (p value = 0.000 and 0.039) respectively. On comparing between patient with good and poor outcome, good outcome was associated with increased serum albumin level at admission (p value = 0.03) respectively. A significant negative correlation was found between total leukocyte count, hematocrit value, and stroke outcome (p value = 0.015 and 0.013) respectively. Only albumin was found to be a significant predictor for outcome by linear regression analysis. CONCLUSION: Serum albumin, hematocrit level, and total leukocyte count at the time of presentation of ischemic stroke are useful markers for stroke outcome. Springer Berlin Heidelberg 2018-07-02 2018 /pmc/articles/PMC6028876/ /pubmed/30046235 http://dx.doi.org/10.1186/s41983-018-0019-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Hashem, Saher S.
Helmy, Sadek M.
El-Fayomy, Nervana M.
Oraby, Mohammed I.
Menshawy, Mohammed
Dawood, Nermin A.
Hashem, Heba S.
Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin
title Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin
title_full Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin
title_fullStr Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin
title_full_unstemmed Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin
title_short Predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin
title_sort predictors of stroke outcome: the role of hemorheology, natural anticoagulants, and serum albumin
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028876/
https://www.ncbi.nlm.nih.gov/pubmed/30046235
http://dx.doi.org/10.1186/s41983-018-0019-x
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