Scc2 Is a Potent Activator of Cohesin’s ATPase that Promotes Loading by Binding Scc1 without Pds5

Cohesin organizes DNA into chromatids, regulates enhancer-promoter interactions, and confers sister chromatid cohesion. Its association with chromosomes is regulated by hook-shaped HEAT repeat proteins that bind Scc1, namely Scc3, Pds5, and Scc2. Unlike Pds5, Scc2 is not a stable cohesin constituent...

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Detalles Bibliográficos
Autores principales: Petela, Naomi J., Gligoris, Thomas G., Metson, Jean, Lee, Byung-Gil, Voulgaris, Menelaos, Hu, Bin, Kikuchi, Sotaro, Chapard, Christophe, Chen, Wentao, Rajendra, Eeson, Srinivisan, Madhusudhan, Yu, Hongtao, Löwe, Jan, Nasmyth, Kim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028919/
https://www.ncbi.nlm.nih.gov/pubmed/29932904
http://dx.doi.org/10.1016/j.molcel.2018.05.022

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