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Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy

BACKGROUND: Expression of COP9 signalosome subunit 3 (COPS3), an oncogene overexpressed in osteosarcoma, has been demonstrated to be significantly correlated with tumor metastasis. However, the underlying mechanism by which COPS3 promotes metastasis of osteosarcoma and its role in autophagy remain u...

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Detalles Bibliográficos
Autores principales:	Zhang, Fan, Yan, Taiqiang, Guo, Wei, Sun, Kunkun, Wang, Shidong, Bao, Xing, Liu, Kuisheng, Zheng, Bingxin, Zhang, Hongliang, Ren, Tingting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029018/ https://www.ncbi.nlm.nih.gov/pubmed/29970115 http://dx.doi.org/10.1186/s13046-018-0791-6

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