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Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors

BACKGROUND: The epidemiology of maternal and infant Group B streptococcus (GBS) colonization is poorly understood in China. The aim of this study is to explore the prevalence and risk factors associated with maternal and infant GBS colonization in Western China. METHODS: From January 2017 to June 20...

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Autores principales: Chen, Jichang, Fu, Jinjian, Du, Wei, Liu, Xin, Rongkavilit, Chokechai, Huang, Xuemei, Wu, Yubi, Wang, Yuanliu, McGrath, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029028/
https://www.ncbi.nlm.nih.gov/pubmed/29970020
http://dx.doi.org/10.1186/s12879-018-3216-4
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author Chen, Jichang
Fu, Jinjian
Du, Wei
Liu, Xin
Rongkavilit, Chokechai
Huang, Xuemei
Wu, Yubi
Wang, Yuanliu
McGrath, Eric
author_facet Chen, Jichang
Fu, Jinjian
Du, Wei
Liu, Xin
Rongkavilit, Chokechai
Huang, Xuemei
Wu, Yubi
Wang, Yuanliu
McGrath, Eric
author_sort Chen, Jichang
collection PubMed
description BACKGROUND: The epidemiology of maternal and infant Group B streptococcus (GBS) colonization is poorly understood in China. The aim of this study is to explore the prevalence and risk factors associated with maternal and infant GBS colonization in Western China. METHODS: From January 2017 to June 2017, a prospective study was conducted to estimate the maternal and infant GBS colonization rate by maternal rectovaginal and infant nasopharynx, ear canal and umbilical swab culture. Patient demographics, clinical characteristics and outcomes were collected. Chi-square and logistic regression analyses were used to examine the risk factors associated with GBS colonization of mothers and infants. RESULTS: The GBS colonization rate in mothers and infants was 6.1 and 0.7%, respectively. The vertical transmission rate was 7.6%. The early onset GBS infection rate was 0.58 per 1000 live births and mortality was 0.29 per 1000 live births. Age younger than 40 years (p = 0.040) and minority ethnic status (p = 0.049) were associated with higher GBS colonization rate in pregnant women. Positive GBS status in the mother prior to delivery (p < 0.001) as well as longer duration of membrane rupture (≥12 h) (p < 0.001) and longer labor (≥4 h) (p < 0.001) were all significant risk factors for GBS colonization in infants. Compared to infants without GBS colonization, infants colonized with GBS were more likely to have had a temperature of ≥38 °C (p < 0.001), developed early onset infection (EOD) (p < 0.001), and been prescribed antibiotics (p < 0.001). Furthermore, infants with GBS were more likely to have been admitted to neonatal intensive unit (NICU) (p < 0.001) with a longer hospital length of stay (LOS) (p < 0.001). CONCLUSIONS: Maternal GBS colonization, longer duration of membrane rupture and labor were all major risk factors associated with GBS colonization in Chinese infants. Infant GBS colonization was associated with increased risk of EOD and NICU admission as well as longer LOS.
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spelling pubmed-60290282018-07-09 Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors Chen, Jichang Fu, Jinjian Du, Wei Liu, Xin Rongkavilit, Chokechai Huang, Xuemei Wu, Yubi Wang, Yuanliu McGrath, Eric BMC Infect Dis Research Article BACKGROUND: The epidemiology of maternal and infant Group B streptococcus (GBS) colonization is poorly understood in China. The aim of this study is to explore the prevalence and risk factors associated with maternal and infant GBS colonization in Western China. METHODS: From January 2017 to June 2017, a prospective study was conducted to estimate the maternal and infant GBS colonization rate by maternal rectovaginal and infant nasopharynx, ear canal and umbilical swab culture. Patient demographics, clinical characteristics and outcomes were collected. Chi-square and logistic regression analyses were used to examine the risk factors associated with GBS colonization of mothers and infants. RESULTS: The GBS colonization rate in mothers and infants was 6.1 and 0.7%, respectively. The vertical transmission rate was 7.6%. The early onset GBS infection rate was 0.58 per 1000 live births and mortality was 0.29 per 1000 live births. Age younger than 40 years (p = 0.040) and minority ethnic status (p = 0.049) were associated with higher GBS colonization rate in pregnant women. Positive GBS status in the mother prior to delivery (p < 0.001) as well as longer duration of membrane rupture (≥12 h) (p < 0.001) and longer labor (≥4 h) (p < 0.001) were all significant risk factors for GBS colonization in infants. Compared to infants without GBS colonization, infants colonized with GBS were more likely to have had a temperature of ≥38 °C (p < 0.001), developed early onset infection (EOD) (p < 0.001), and been prescribed antibiotics (p < 0.001). Furthermore, infants with GBS were more likely to have been admitted to neonatal intensive unit (NICU) (p < 0.001) with a longer hospital length of stay (LOS) (p < 0.001). CONCLUSIONS: Maternal GBS colonization, longer duration of membrane rupture and labor were all major risk factors associated with GBS colonization in Chinese infants. Infant GBS colonization was associated with increased risk of EOD and NICU admission as well as longer LOS. BioMed Central 2018-07-03 /pmc/articles/PMC6029028/ /pubmed/29970020 http://dx.doi.org/10.1186/s12879-018-3216-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Chen, Jichang
Fu, Jinjian
Du, Wei
Liu, Xin
Rongkavilit, Chokechai
Huang, Xuemei
Wu, Yubi
Wang, Yuanliu
McGrath, Eric
Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors
title Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors
title_full Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors
title_fullStr Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors
title_full_unstemmed Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors
title_short Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors
title_sort group b streptococcal colonization in mothers and infants in western china: prevalences and risk factors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029028/
https://www.ncbi.nlm.nih.gov/pubmed/29970020
http://dx.doi.org/10.1186/s12879-018-3216-4
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