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Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate DA neuronal degeneration in the substantia nigra. The infiltration and transformation of immune cells from the peripheral...

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Detalles Bibliográficos
Autores principales:	Qiao, Chen, Zhang, Qian, Jiang, Qingling, Zhang, Ting, Chen, Miaomiao, Fan, Yi, Ding, Jianhua, Lu, Ming, Hu, Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029067/ https://www.ncbi.nlm.nih.gov/pubmed/29966531 http://dx.doi.org/10.1186/s12974-018-1236-z

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