The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility...

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Autores principales: Granata, Vincenza, Fusco, Roberta, Filice, Salvatore, Catalano, Orlando, Piccirillo, Mauro, Palaia, Raffaele, Izzo, Francesco, Petrillo, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029348/
https://www.ncbi.nlm.nih.gov/pubmed/29988667
http://dx.doi.org/10.1186/s13027-018-0194-5
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author Granata, Vincenza
Fusco, Roberta
Filice, Salvatore
Catalano, Orlando
Piccirillo, Mauro
Palaia, Raffaele
Izzo, Francesco
Petrillo, Antonella
author_facet Granata, Vincenza
Fusco, Roberta
Filice, Salvatore
Catalano, Orlando
Piccirillo, Mauro
Palaia, Raffaele
Izzo, Francesco
Petrillo, Antonella
author_sort Granata, Vincenza
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.
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spelling pubmed-60293482018-07-09 The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC Granata, Vincenza Fusco, Roberta Filice, Salvatore Catalano, Orlando Piccirillo, Mauro Palaia, Raffaele Izzo, Francesco Petrillo, Antonella Infect Agent Cancer Review Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade. BioMed Central 2018-07-03 /pmc/articles/PMC6029348/ /pubmed/29988667 http://dx.doi.org/10.1186/s13027-018-0194-5 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Granata, Vincenza
Fusco, Roberta
Filice, Salvatore
Catalano, Orlando
Piccirillo, Mauro
Palaia, Raffaele
Izzo, Francesco
Petrillo, Antonella
The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_full The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_fullStr The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_full_unstemmed The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_short The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_sort current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of hcc
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029348/
https://www.ncbi.nlm.nih.gov/pubmed/29988667
http://dx.doi.org/10.1186/s13027-018-0194-5
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