Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M(1)R) is a metabotropic G protein-coupled receptor. Knockout of M(1)R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested...

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Detalles Bibliográficos
Autores principales: Sabbir, Mohammad G., Calcutt, Nigel A., Fernyhough, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029366/
https://www.ncbi.nlm.nih.gov/pubmed/29997469
http://dx.doi.org/10.3389/fnins.2018.00402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029366/
https://www.ncbi.nlm.nih.gov/pubmed/29997469
http://dx.doi.org/10.3389/fnins.2018.00402

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