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Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden

BACKGROUND: According to the literature the three stone diseases, sialolithiasis (SL), urolithiasis (UL) and cholelithiasis (CL) share comorbidities. We assess familial and spouse risks between these stone disease and compare them to familial risks for concordant (same) stone disease. METHODS: Study...

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Autores principales: Hemminki, Kari, Hemminki, Otto, Koskinen, Anni I. M., Försti, Asta, Sundquist, Kristina, Sundquist, Jan, Li, Xinjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029375/
https://www.ncbi.nlm.nih.gov/pubmed/29970034
http://dx.doi.org/10.1186/s12882-018-0945-y
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author Hemminki, Kari
Hemminki, Otto
Koskinen, Anni I. M.
Försti, Asta
Sundquist, Kristina
Sundquist, Jan
Li, Xinjun
author_facet Hemminki, Kari
Hemminki, Otto
Koskinen, Anni I. M.
Försti, Asta
Sundquist, Kristina
Sundquist, Jan
Li, Xinjun
author_sort Hemminki, Kari
collection PubMed
description BACKGROUND: According to the literature the three stone diseases, sialolithiasis (SL), urolithiasis (UL) and cholelithiasis (CL) share comorbidities. We assess familial and spouse risks between these stone disease and compare them to familial risks for concordant (same) stone disease. METHODS: Study population including familiar relationships was obtained from the Swedish Multigeneration Register and stone disease patients were identified from nation-wide medical records. Standardized incidence ratios (SIRs) were calculated for 0–83 year old offspring when their first-degree relatives were diagnosed with stone disease and the rates were compared to individuals without a family history of stone disease. Numbers of offspring with SL were 7906, for UL they were 170,757 and for CL they were 204,369. RESULTS: SIRs for concordant familial risks were 2.06 for SL, 1.94 for UL and 1.82 for CL. SIRs for SL and UL were slightly higher for women than for men. Familial risks between stone diseases were modest. The highest risk of 1.17 was for UL when family members were diagnosed with CL, or vice versa. The SIR for UL was 1.15 when family members were diagnosed with SL. Familial risks among spouses were increased only for UL-CL pairs (1.10). CONCLUSIONS: Familial risks for concordant SL were 2.06 and marginally lower for the other diseases. Familial risks between stone diseases were low but higher than risks between spouses. The data show that familial clustering is unique to each individual stone disease which would imply distinct disease mechanisms. The results cast doubt on the reported comorbidities between these diseases.
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spelling pubmed-60293752018-07-09 Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden Hemminki, Kari Hemminki, Otto Koskinen, Anni I. M. Försti, Asta Sundquist, Kristina Sundquist, Jan Li, Xinjun BMC Nephrol Research Article BACKGROUND: According to the literature the three stone diseases, sialolithiasis (SL), urolithiasis (UL) and cholelithiasis (CL) share comorbidities. We assess familial and spouse risks between these stone disease and compare them to familial risks for concordant (same) stone disease. METHODS: Study population including familiar relationships was obtained from the Swedish Multigeneration Register and stone disease patients were identified from nation-wide medical records. Standardized incidence ratios (SIRs) were calculated for 0–83 year old offspring when their first-degree relatives were diagnosed with stone disease and the rates were compared to individuals without a family history of stone disease. Numbers of offspring with SL were 7906, for UL they were 170,757 and for CL they were 204,369. RESULTS: SIRs for concordant familial risks were 2.06 for SL, 1.94 for UL and 1.82 for CL. SIRs for SL and UL were slightly higher for women than for men. Familial risks between stone diseases were modest. The highest risk of 1.17 was for UL when family members were diagnosed with CL, or vice versa. The SIR for UL was 1.15 when family members were diagnosed with SL. Familial risks among spouses were increased only for UL-CL pairs (1.10). CONCLUSIONS: Familial risks for concordant SL were 2.06 and marginally lower for the other diseases. Familial risks between stone diseases were low but higher than risks between spouses. The data show that familial clustering is unique to each individual stone disease which would imply distinct disease mechanisms. The results cast doubt on the reported comorbidities between these diseases. BioMed Central 2018-07-03 /pmc/articles/PMC6029375/ /pubmed/29970034 http://dx.doi.org/10.1186/s12882-018-0945-y Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Hemminki, Kari
Hemminki, Otto
Koskinen, Anni I. M.
Försti, Asta
Sundquist, Kristina
Sundquist, Jan
Li, Xinjun
Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden
title Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden
title_full Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden
title_fullStr Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden
title_full_unstemmed Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden
title_short Familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of Sweden
title_sort familial risks in and between stone diseases: sialolithiasis, urolithiasis and cholelithiasis in the population of sweden
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029375/
https://www.ncbi.nlm.nih.gov/pubmed/29970034
http://dx.doi.org/10.1186/s12882-018-0945-y
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