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Alternanthera mosaic potexvirus: Several Features, Properties, and Application

Alternanthera mosaic virus (AltMV) is a typical member of the Potexvirus genus in its morphology and genome structure; still it exhibits a number of unique features. They allow this virus to be considered a promising object for biotechnology. Virions and virus-like particles (VLPs) of AltMV are stab...

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Autores principales: Donchenko, Ekaterina, Trifonova, Ekaterina, Nikitin, Nikolai, Atabekov, Joseph, Karpova, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029478/
https://www.ncbi.nlm.nih.gov/pubmed/30018641
http://dx.doi.org/10.1155/2018/1973705
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author Donchenko, Ekaterina
Trifonova, Ekaterina
Nikitin, Nikolai
Atabekov, Joseph
Karpova, Olga
author_facet Donchenko, Ekaterina
Trifonova, Ekaterina
Nikitin, Nikolai
Atabekov, Joseph
Karpova, Olga
author_sort Donchenko, Ekaterina
collection PubMed
description Alternanthera mosaic virus (AltMV) is a typical member of the Potexvirus genus in its morphology and genome structure; still it exhibits a number of unique features. They allow this virus to be considered a promising object for biotechnology. Virions and virus-like particles (VLPs) of AltMV are stable in a wide range of conditions, including sera of laboratory animals. AltMV VLPs can assemble at various pH and ionic strengths. Furthermore, AltMV virions and VLPs demonstrate high immunogenicity, enhancing the immune response to the target antigen thus offering the possibility of being used as potential adjuvants. Recently, for the first time for plant viruses, we showed the structural difference between morphologically similar viral and virus-like particles on AltMV virions and VLPs. In this review, we discuss the features of AltMV virions, AltMV VLP assembly, and their structure and properties, as well as the characteristics of AltMV isolates, host plants, infection symptoms, AltMV isolation and purification, genome structure, viral proteins, and AltMV-based vectors.
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spelling pubmed-60294782018-07-17 Alternanthera mosaic potexvirus: Several Features, Properties, and Application Donchenko, Ekaterina Trifonova, Ekaterina Nikitin, Nikolai Atabekov, Joseph Karpova, Olga Adv Virol Review Article Alternanthera mosaic virus (AltMV) is a typical member of the Potexvirus genus in its morphology and genome structure; still it exhibits a number of unique features. They allow this virus to be considered a promising object for biotechnology. Virions and virus-like particles (VLPs) of AltMV are stable in a wide range of conditions, including sera of laboratory animals. AltMV VLPs can assemble at various pH and ionic strengths. Furthermore, AltMV virions and VLPs demonstrate high immunogenicity, enhancing the immune response to the target antigen thus offering the possibility of being used as potential adjuvants. Recently, for the first time for plant viruses, we showed the structural difference between morphologically similar viral and virus-like particles on AltMV virions and VLPs. In this review, we discuss the features of AltMV virions, AltMV VLP assembly, and their structure and properties, as well as the characteristics of AltMV isolates, host plants, infection symptoms, AltMV isolation and purification, genome structure, viral proteins, and AltMV-based vectors. Hindawi 2018-06-19 /pmc/articles/PMC6029478/ /pubmed/30018641 http://dx.doi.org/10.1155/2018/1973705 Text en Copyright © 2018 Ekaterina Donchenko et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Donchenko, Ekaterina
Trifonova, Ekaterina
Nikitin, Nikolai
Atabekov, Joseph
Karpova, Olga
Alternanthera mosaic potexvirus: Several Features, Properties, and Application
title Alternanthera mosaic potexvirus: Several Features, Properties, and Application
title_full Alternanthera mosaic potexvirus: Several Features, Properties, and Application
title_fullStr Alternanthera mosaic potexvirus: Several Features, Properties, and Application
title_full_unstemmed Alternanthera mosaic potexvirus: Several Features, Properties, and Application
title_short Alternanthera mosaic potexvirus: Several Features, Properties, and Application
title_sort alternanthera mosaic potexvirus: several features, properties, and application
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029478/
https://www.ncbi.nlm.nih.gov/pubmed/30018641
http://dx.doi.org/10.1155/2018/1973705
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