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Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases
Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the r...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029501/ https://www.ncbi.nlm.nih.gov/pubmed/30018639 http://dx.doi.org/10.1155/2018/4579734 |
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author | Mellouk, Namya Ramé, Christelle Barbe, Alix Grandhaye, Jérémy Froment, Pascal Dupont, Joëlle |
author_facet | Mellouk, Namya Ramé, Christelle Barbe, Alix Grandhaye, Jérémy Froment, Pascal Dupont, Joëlle |
author_sort | Mellouk, Namya |
collection | PubMed |
description | Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species. |
format | Online Article Text |
id | pubmed-6029501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60295012018-07-17 Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases Mellouk, Namya Ramé, Christelle Barbe, Alix Grandhaye, Jérémy Froment, Pascal Dupont, Joëlle Int J Endocrinol Review Article Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species. Hindawi 2018-06-19 /pmc/articles/PMC6029501/ /pubmed/30018639 http://dx.doi.org/10.1155/2018/4579734 Text en Copyright © 2018 Namya Mellouk et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mellouk, Namya Ramé, Christelle Barbe, Alix Grandhaye, Jérémy Froment, Pascal Dupont, Joëlle Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases |
title | Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases |
title_full | Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases |
title_fullStr | Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases |
title_full_unstemmed | Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases |
title_short | Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases |
title_sort | chicken is a useful model to investigate the role of adipokines in metabolic and reproductive diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029501/ https://www.ncbi.nlm.nih.gov/pubmed/30018639 http://dx.doi.org/10.1155/2018/4579734 |
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