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Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the r...

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Autores principales: Mellouk, Namya, Ramé, Christelle, Barbe, Alix, Grandhaye, Jérémy, Froment, Pascal, Dupont, Joëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029501/
https://www.ncbi.nlm.nih.gov/pubmed/30018639
http://dx.doi.org/10.1155/2018/4579734
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author Mellouk, Namya
Ramé, Christelle
Barbe, Alix
Grandhaye, Jérémy
Froment, Pascal
Dupont, Joëlle
author_facet Mellouk, Namya
Ramé, Christelle
Barbe, Alix
Grandhaye, Jérémy
Froment, Pascal
Dupont, Joëlle
author_sort Mellouk, Namya
collection PubMed
description Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species.
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spelling pubmed-60295012018-07-17 Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases Mellouk, Namya Ramé, Christelle Barbe, Alix Grandhaye, Jérémy Froment, Pascal Dupont, Joëlle Int J Endocrinol Review Article Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species. Hindawi 2018-06-19 /pmc/articles/PMC6029501/ /pubmed/30018639 http://dx.doi.org/10.1155/2018/4579734 Text en Copyright © 2018 Namya Mellouk et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mellouk, Namya
Ramé, Christelle
Barbe, Alix
Grandhaye, Jérémy
Froment, Pascal
Dupont, Joëlle
Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases
title Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases
title_full Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases
title_fullStr Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases
title_full_unstemmed Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases
title_short Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases
title_sort chicken is a useful model to investigate the role of adipokines in metabolic and reproductive diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029501/
https://www.ncbi.nlm.nih.gov/pubmed/30018639
http://dx.doi.org/10.1155/2018/4579734
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