Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation

SET domain containing 2 (Setd2), encoding a histone methyltransferase, is associated with many hematopoietic diseases when mutated. By generating a novel exon 6 conditional knockout mouse model, we describe an essential role of Setd2 in maintaining the adult hematopoietic stem cells. Loss of Setd2 r...

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Detalles Bibliográficos
Autores principales: Zhou, Yile, Yan, Xiaomei, Feng, Xiaomin, Bu, Jiachen, Dong, Yunzhu, Lin, Peipei, Hayashi, Yoshihiro, Huang, Rui, Olsson, Andre, Andreassen, Paul R., Grimes, H. Leighton, Wang, Qian-fei, Cheng, Tao, Xiao, Zhijian, Jin, Jie, Huang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029524/
https://www.ncbi.nlm.nih.gov/pubmed/29650642
http://dx.doi.org/10.3324/haematol.2018.187708

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