Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment

The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes. In a prior drug repurposing screen, we identified tofacitinib, a pa...

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Detalles Bibliográficos
Autores principales: Lam, Christine, Ferguson, Ian D., Mariano, Margarette C., Lin, Yu-Hsiu T., Murnane, Megan, Liu, Hui, Smith, Geoffrey A., Wong, Sandy W., Taunton, Jack, Liu, Jun O., Mitsiades, Constantine S., Hann, Byron C., Aftab, Blake T., Wiita, Arun P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029548/
https://www.ncbi.nlm.nih.gov/pubmed/29622655
http://dx.doi.org/10.3324/haematol.2017.174482

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