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Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism
CRTh2 (encoded by PTGDR2) is a G-protein coupled receptor expressed by Th2 cells as well as eosinophils, basophils and innate lymphoid cells (ILC)2s. Activation of CRTh2, by its ligand prostaglandin (PG)D(2), mediates production of type 2 cytokines (IL-4, IL-5 and IL-13), chemotaxis and inhibition o...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029763/ https://www.ncbi.nlm.nih.gov/pubmed/29969451 http://dx.doi.org/10.1371/journal.pone.0199156 |