Loss of protein phosphatase 6 in mouse keratinocytes enhances K‐ras (G12D)‐driven tumor promotion

Here, we address the function of protein phosphatase 6 (PP6) loss on K‐ras‐initiated tumorigenesis in keratinocytes. To do so, we developed tamoxifen‐inducible double mutant (K‐ras (G12D)‐expressing and Ppp6c‐deficient) mice in which K‐ras (G12D) expression is driven by the cytokeratin 14 (K14) prom...

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Detalles Bibliográficos
Autores principales: Kurosawa, Koreyuki, Inoue, Yui, Kakugawa, Yoichiro, Yamashita, Yoji, Kanazawa, Kosuke, Kishimoto, Kazuhiro, Nomura, Miyuki, Momoi, Yuki, Sato, Ikuro, Chiba, Natsuko, Suzuki, Mai, Ogoh, Honami, Yamada, Hidekazu, Miura, Koh, Watanabe, Toshio, Tanuma, Nobuhiro, Tachi, Masahiro, Shima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029815/
https://www.ncbi.nlm.nih.gov/pubmed/29758119
http://dx.doi.org/10.1111/cas.13638

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