Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis

Matrix stiffening with downstream activation of mechanosensitive pathways is strongly implicated in progressive fibrosis; however, pathologic changes in extracellular matrix (ECM) that initiate mechano-homeostasis dysregulation are not defined in human disease. By integrated multiscale biomechanical...

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Detalles Bibliográficos
Autores principales: Jones, Mark G, Andriotis, Orestis G, Roberts, James JW, Lunn, Kerry, Tear, Victoria J, Cao, Lucy, Ask, Kjetil, Smart, David E, Bonfanti, Alessandra, Johnson, Peter, Alzetani, Aiman, Conforti, Franco, Doherty, Regan, Lai, Chester Y, Johnson, Benjamin, Bourdakos, Konstantinos N, Fletcher, Sophie V, Marshall, Ben G, Jogai, Sanjay, Brereton, Christopher J, Chee, Serena J, Ottensmeier, Christian H, Sime, Patricia, Gauldie, Jack, Kolb, Martin, Mahajan, Sumeet, Fabre, Aurelie, Bhaskar, Atul, Jarolimek, Wolfgang, Richeldi, Luca, O'Reilly, Katherine MA, Monk, Phillip D, Thurner, Philipp J, Davies, Donna E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029847/
https://www.ncbi.nlm.nih.gov/pubmed/29966587
http://dx.doi.org/10.7554/eLife.36354

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