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Low-dose irradiation of mouse embryos increases Smad-p21 pathway activity and preserves pluripotency

PURPOSE: To study the outcomes of mouse preimplantation embryos irradiated with low doses of X-rays (≤ 1 Gy) and investigate apoptosis and pluripotency of the irradiated embryos. METHODS: Mouse embryos at the 2-cell stage were collected for in vitro culture. After reaching the 8-cell stage, embryos...

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Detalles Bibliográficos
Autores principales:	Hayashi, Masami, Yoshida, Kayo, Kitada, Kohei, Kizu, Akane, Tachibana, Daisuke, Fukui, Mitsuru, Morita, Takashi, Koyama, Masayasu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Embryo Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030001/ https://www.ncbi.nlm.nih.gov/pubmed/29546598 http://dx.doi.org/10.1007/s10815-018-1156-y

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