Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus

Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here, we show that a fraction of cytoplasmic AURKA is associated with mitochond...

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Detalles Bibliográficos
Autores principales: Grant, Rhys, Abdelbaki, Ahmed, Bertoldi, Alessia, Gavilan, Maria P., Mansfeld, Jörg, Glover, David M., Lindon, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030116/
https://www.ncbi.nlm.nih.gov/pubmed/29899121
http://dx.doi.org/10.1098/rsob.170272

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