Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry

There is a growing body of evidence to support the involvement of proinflammatory cytokines in the pathophysiology of depression; however, no previous studies have examined the relationship between cytokines and the brain morphology of patients with major depressive disorder (MDD). We therefore eval...

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Autores principales: Kakeda, Shingo, Watanabe, Keita, Katsuki, Asuka, Sugimoto, Koichiro, Igata, Natsuki, Ueda, Issei, Igata, Ryohei, Abe, Osamu, Yoshimura, Reiji, Korogi, Yukunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030126/
https://www.ncbi.nlm.nih.gov/pubmed/29968776
http://dx.doi.org/10.1038/s41598-018-28300-5
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author Kakeda, Shingo
Watanabe, Keita
Katsuki, Asuka
Sugimoto, Koichiro
Igata, Natsuki
Ueda, Issei
Igata, Ryohei
Abe, Osamu
Yoshimura, Reiji
Korogi, Yukunori
author_facet Kakeda, Shingo
Watanabe, Keita
Katsuki, Asuka
Sugimoto, Koichiro
Igata, Natsuki
Ueda, Issei
Igata, Ryohei
Abe, Osamu
Yoshimura, Reiji
Korogi, Yukunori
author_sort Kakeda, Shingo
collection PubMed
description There is a growing body of evidence to support the involvement of proinflammatory cytokines in the pathophysiology of depression; however, no previous studies have examined the relationship between cytokines and the brain morphology of patients with major depressive disorder (MDD). We therefore evaluated the relationship between serum cytokine levels and cortical thinning during the first depressive episode in drug-naïve patients with MDD. We measured the serum cytokine levels (IL-1β, IL-6, IFN-γ, and TNFα), and whole-brain cortical thickness and hippocampal subfield volumes on brain magnetic resonance imaging (MRI) using surface-based morphometry in 40 patients with MDD and 47 healthy volunteers (controls). Only the serum IL-6 level was significantly higher in patients with MDD than in controls. The prefrontal cortex (PFC) thickness was significantly reduced in patients with MDD, and showed a significant inverse correlation with the serum IL-6 level. Although high serum IL-6 levels were correlated with reduced left subiculum and right CA1, CA3, CA4, GC-DG, subiculum, and whole hippocampus volumes, the presence or absence of MDD had no effect on the volume of any hippocampal subfields. Our results suggest that IL-6 may play a key role in the morphological changes in the PFC during the early stage of MDD.
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spelling pubmed-60301262018-07-11 Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry Kakeda, Shingo Watanabe, Keita Katsuki, Asuka Sugimoto, Koichiro Igata, Natsuki Ueda, Issei Igata, Ryohei Abe, Osamu Yoshimura, Reiji Korogi, Yukunori Sci Rep Article There is a growing body of evidence to support the involvement of proinflammatory cytokines in the pathophysiology of depression; however, no previous studies have examined the relationship between cytokines and the brain morphology of patients with major depressive disorder (MDD). We therefore evaluated the relationship between serum cytokine levels and cortical thinning during the first depressive episode in drug-naïve patients with MDD. We measured the serum cytokine levels (IL-1β, IL-6, IFN-γ, and TNFα), and whole-brain cortical thickness and hippocampal subfield volumes on brain magnetic resonance imaging (MRI) using surface-based morphometry in 40 patients with MDD and 47 healthy volunteers (controls). Only the serum IL-6 level was significantly higher in patients with MDD than in controls. The prefrontal cortex (PFC) thickness was significantly reduced in patients with MDD, and showed a significant inverse correlation with the serum IL-6 level. Although high serum IL-6 levels were correlated with reduced left subiculum and right CA1, CA3, CA4, GC-DG, subiculum, and whole hippocampus volumes, the presence or absence of MDD had no effect on the volume of any hippocampal subfields. Our results suggest that IL-6 may play a key role in the morphological changes in the PFC during the early stage of MDD. Nature Publishing Group UK 2018-07-03 /pmc/articles/PMC6030126/ /pubmed/29968776 http://dx.doi.org/10.1038/s41598-018-28300-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kakeda, Shingo
Watanabe, Keita
Katsuki, Asuka
Sugimoto, Koichiro
Igata, Natsuki
Ueda, Issei
Igata, Ryohei
Abe, Osamu
Yoshimura, Reiji
Korogi, Yukunori
Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
title Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
title_full Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
title_fullStr Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
title_full_unstemmed Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
title_short Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
title_sort relationship between interleukin (il)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030126/
https://www.ncbi.nlm.nih.gov/pubmed/29968776
http://dx.doi.org/10.1038/s41598-018-28300-5
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